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- W2075553662 abstract "Presented here is a quantitative model of the wrapping and unwrapping of the DNA around the histone core of the nucleosome that suggests a mechanism by which this transition can be controlled: alteration of the charge state of the globular histone core. The mechanism is relevant to several classes of posttranslational modifications such as histone acetylation and phosphorylation; several specific scenarios consistent with recent in vivo experiments are considered. The model integrates a description based on an idealized geometry with one based on the atomistic structure of the nucleosome, and the model consistently accounts for both the electrostatic and nonelectrostatic contributions to the nucleosome free energy. Under physiological conditions, isolated nucleosomes are predicted to be very stable (38 +/- 7 kcal/mol). However, a decrease in the charge of the globular histone core by one unit charge, for example due to acetylation of a single lysine residue, can lead to a significant decrease in the strength of association with its DNA. In contrast to the globular histone core, comparable changes in the charge state of the histone tail regions have relatively little effect on the nucleosome's stability. The combination of high stability and sensitivity explains how the nucleosome is able to satisfy the seemingly contradictory requirements for thermodynamic stability while allowing quick access to its DNA informational content when needed by specific cellular processes such as transcription." @default.
- W2075553662 created "2016-06-24" @default.
- W2075553662 creator A5022075325 @default.
- W2075553662 creator A5033586858 @default.
- W2075553662 creator A5046489889 @default.
- W2075553662 date "2010-09-01" @default.
- W2075553662 modified "2023-10-10" @default.
- W2075553662 title "Charge State of the Globular Histone Core Controls Stability of the Nucleosome" @default.
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- W2075553662 doi "https://doi.org/10.1016/j.bpj.2010.06.046" @default.
- W2075553662 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2931741" @default.
- W2075553662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20816070" @default.
- W2075553662 hasPublicationYear "2010" @default.
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