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• W2075567629 abstract "<i>Objective:</i> To investigate the utilization of T-cell receptor (TCR) variable (V) regions in infiltrates of sural nerve biopsies of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and vasculitic neuropathy. <i>Background:</i> The presence of infiltrating T lymphocytes in sural nerve biopsies may suggest a T cell-mediated immune mechanism in the pathogenesis of CIDP and vasculitic neuropathy. <i>Patients and methods:</i> The utilization of TCR Vβ regions in sural nerves of 13 patients with CIDP and five patients with vasculitic neuropathy was determined by immunohistochemistry, reverse-transcription PCR, and nucleotide sequence analysis. These techniques were also applied in four patients with chronic idiopathic axonal polyneuropathy (CIAP) who acted as noninflammatory controls, and in five autopsy controls. <i>Results:</i> The TCR Vβ utilization of infiltrating T cells in sural nerves of patients with CIDP, vasculitic neuropathy, and noninflammatory controls is heterogeneous. A dominant TCR Vβ utilization was not found in any of the patients or controls. <i>Conclusion:</i> There is no evidence for the presence of clonally expanded T cells in sural nerves of patients with CIDP and vasculitic neuropathy." @default.
• W2075567629 created "2016-06-24" @default.
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• W2075567629 date "2001-01-09" @default.
• W2075567629 modified "2023-09-27" @default.
• W2075567629 title "Sural nerve T-cell receptor Vβ gene utilization in chronic inflammatory demyelinating polyneuropathy and vasculitic neuropathy" @default.
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• W2075567629 doi "https://doi.org/10.1212/wnl.56.1.74" @default.
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