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- W2075586195 abstract "Carvedilol (BM 14.190) has been shown to have β-adrenergic blocking and vasodilating activity. By means of digital plethysmography, the threshold for vasodilation was ascertained at a dose of 2.6 mg iv infused over 1 hour. The oral threshold dose was established at about 15 mg, with a linear increase in response (r = 0.78) up to 76.5 mg. This dose increased blood flow to the forearm by reduction of arterial resistance. Although venous capacity was not changed, postural symptoms in three subjects could also be indicative of venous involvement. Carvedilol, 50 mg, reduced exercise heart rate for about 10 hours. Clinical Pharmacology and Therapeutics (1986) 39, 677–682; doi:10.1038/clpt.1986.118" @default.
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- W2075586195 date "1986-06-01" @default.
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- W2075586195 title "Clinical pharmacologic investigations with carvedilol, a new beta-blocker with direct vasodilator activity" @default.
- W2075586195 doi "https://doi.org/10.1038/clpt.1986.118" @default.
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