FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075588585> ?p ?o ?g. }

• W2075588585 endingPage "145" @default.
• W2075588585 startingPage "139" @default.
• W2075588585 abstract "In most developing countries, 70-80% of the population still resort to traditional medicine for their primary health care. This medicine utilises medicinal plants which are traditionally taken as concoction and infusion. The root and stem bark of Millettia griffoniana (Leguminosae), has been reported to contain isoflavonoids, alkaloids, and diterpenoids. The possible benefit of some bioactive isoflavones derived from M. griffoniana prompted us to screen them for estrogenic activity. Six isoflavones and coumarin derived from M. griffoniana (bail) namely, compound nos. 1-6 (Fig. 1) were tested for their potential estrogenic activities in three different estrogen receptor alpha (ERalpha)-dependent assays. In a yeast-based ERalpha assay, all test substances and 17beta-estradiol as endogenous agonist, showed a significant induction of beta-galactosidase activity. The test compounds at the concentration of 5 x 10(-6) M could achieve 59-121% of the beta-galactosidase induction obtained with 10(-8) M 17beta-estradiol (100%). In the reporter gene assay based on stably transfected MCF-7 cells (MVLN cells), the estrogen responsive induction of luciferase was also stimulated by the M. griffoniana isoflavones. In Ishikawa cells, all substances exhibited estrogenic activity revealed by the induction of alkaline phosphatase (AlkP) activity. The estrogenic activities of isoflavones from M. griffoniana could be completely suppressed by the pure estrogen antagonist, ICI 182,780, suggesting that the compounds exert their activities through ERalpha. Although all substances showed estrogenic effects, 4'-methoxy-7-O-[(E)-3-methyl-7-hydroxymethyl-2,6-octadienyl]isoflavone (7-O-DHF), Griffonianone C (GRIF-C), and 3',4'-dihydroxy-7-O-[(E)-3,7-dimethyl-2,6-octadienyl]isoflavone (7-O-GISO) were found to be the most potent of tested substances. In summary, estrogenic activities of the isoflavones derived from M. griffoniana were described for the first time using reporter gene assays and the estrogen-inducible AlkP Ishikawa model." @default.
• W2075588585 created "2016-06-24" @default.
• W2075588585 creator A5010433025 @default.
• W2075588585 creator A5024279250 @default.
• W2075588585 creator A5030916048 @default.
• W2075588585 creator A5038377340 @default.
• W2075588585 creator A5041748834 @default.
• W2075588585 creator A5064705952 @default.
• W2075588585 creator A5073307786 @default.
• W2075588585 creator A5078810102 @default.
• W2075588585 creator A5089512855 @default.
• W2075588585 date "2006-02-01" @default.
• W2075588585 modified "2023-10-12" @default.
• W2075588585 title "Estrogenic properties of isoflavones derived from Millettia griffoniana" @default.
• W2075588585 cites W123521375 @default.
• W2075588585 cites W1964535481 @default.
• W2075588585 cites W1984777843 @default.
• W2075588585 cites W1990319541 @default.
• W2075588585 cites W1991710824 @default.
• W2075588585 cites W2022792151 @default.
• W2075588585 cites W2026159928 @default.
• W2075588585 cites W2026836636 @default.
• W2075588585 cites W2029030055 @default.
• W2075588585 cites W2035966078 @default.
• W2075588585 cites W204699962 @default.
• W2075588585 cites W2066715924 @default.
• W2075588585 cites W2087836560 @default.
• W2075588585 cites W2108241608 @default.
• W2075588585 cites W2135730400 @default.
• W2075588585 cites W2137774877 @default.
• W2075588585 cites W2143928322 @default.
• W2075588585 cites W2147762009 @default.
• W2075588585 cites W2157255047 @default.
• W2075588585 cites W2160143312 @default.
• W2075588585 cites W4231298489 @default.
• W2075588585 cites W4249531809 @default.
• W2075588585 cites W4251409858 @default.
• W2075588585 doi "https://doi.org/10.1016/j.phymed.2005.06.003" @default.
• W2075588585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16428019" @default.
• W2075588585 hasPublicationYear "2006" @default.
• W2075588585 type Work @default.
• W2075588585 sameAs 2075588585 @default.
• W2075588585 citedByCount "39" @default.
• W2075588585 countsByYear W20755885852012 @default.
• W2075588585 countsByYear W20755885852013 @default.
• W2075588585 countsByYear W20755885852014 @default.
• W2075588585 countsByYear W20755885852015 @default.
• W2075588585 countsByYear W20755885852017 @default.
• W2075588585 countsByYear W20755885852018 @default.
• W2075588585 countsByYear W20755885852019 @default.
• W2075588585 countsByYear W20755885852020 @default.
• W2075588585 countsByYear W20755885852022 @default.
• W2075588585 countsByYear W20755885852023 @default.
• W2075588585 crossrefType "journal-article" @default.
• W2075588585 hasAuthorship W2075588585A5010433025 @default.
• W2075588585 hasAuthorship W2075588585A5024279250 @default.
• W2075588585 hasAuthorship W2075588585A5030916048 @default.
• W2075588585 hasAuthorship W2075588585A5038377340 @default.
• W2075588585 hasAuthorship W2075588585A5041748834 @default.
• W2075588585 hasAuthorship W2075588585A5064705952 @default.
• W2075588585 hasAuthorship W2075588585A5073307786 @default.
• W2075588585 hasAuthorship W2075588585A5078810102 @default.
• W2075588585 hasAuthorship W2075588585A5089512855 @default.
• W2075588585 hasConcept C121608353 @default.
• W2075588585 hasConcept C126322002 @default.
• W2075588585 hasConcept C134018914 @default.
• W2075588585 hasConcept C172313692 @default.
• W2075588585 hasConcept C185592680 @default.
• W2075588585 hasConcept C2777164284 @default.
• W2075588585 hasConcept C2778270713 @default.
• W2075588585 hasConcept C2779705811 @default.
• W2075588585 hasConcept C2908647359 @default.
• W2075588585 hasConcept C530470458 @default.
• W2075588585 hasConcept C55493867 @default.
• W2075588585 hasConcept C71924100 @default.
• W2075588585 hasConcept C84606932 @default.
• W2075588585 hasConcept C86803240 @default.
• W2075588585 hasConcept C96307122 @default.
• W2075588585 hasConcept C98274493 @default.
• W2075588585 hasConcept C99454951 @default.
• W2075588585 hasConceptScore W2075588585C121608353 @default.
• W2075588585 hasConceptScore W2075588585C126322002 @default.
• W2075588585 hasConceptScore W2075588585C134018914 @default.
• W2075588585 hasConceptScore W2075588585C172313692 @default.
• W2075588585 hasConceptScore W2075588585C185592680 @default.
• W2075588585 hasConceptScore W2075588585C2777164284 @default.
• W2075588585 hasConceptScore W2075588585C2778270713 @default.
• W2075588585 hasConceptScore W2075588585C2779705811 @default.
• W2075588585 hasConceptScore W2075588585C2908647359 @default.
• W2075588585 hasConceptScore W2075588585C530470458 @default.
• W2075588585 hasConceptScore W2075588585C55493867 @default.
• W2075588585 hasConceptScore W2075588585C71924100 @default.
• W2075588585 hasConceptScore W2075588585C84606932 @default.
• W2075588585 hasConceptScore W2075588585C86803240 @default.
• W2075588585 hasConceptScore W2075588585C96307122 @default.
• W2075588585 hasConceptScore W2075588585C98274493 @default.
• W2075588585 hasConceptScore W2075588585C99454951 @default.
• W2075588585 hasIssue "3" @default.

• next