FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075589177> ?p ?o ?g. }

• W2075589177 endingPage "85" @default.
• W2075589177 startingPage "81" @default.
• W2075589177 abstract "As the first step in the process of carcinogenesis, most chemical carcinogens require metabolic activation by cytochromes P450 for conversion to highly reactive electrophiles that bind covalently to DNA. Studies in rodents suggest that low or high levels of expression of a single P450 can determine susceptibility or resistance to chemically induced cancer. Although rodent systems have been used to explore the molecular basis of chemical carcinogenesis and to identify chemicals capable of damaging genes and causing cancer, it has been understood that marked species differences exist in the expression, regulation, and catalytic activities of different P450s. Thus, large efforts are underway to study the catalytic activities of human P450s directly by expression of their cDNAs in cultured cells. Two systems are being used: a) transient high-level P450 production in HepG2 cells for analysis of catalytic activities, and b) stable expression in human B-lymphoblastoid cells to study promutagen and procarcinogen activation. These studies define the relative contributions of individual P450 forms to the activation of various chemical carcinogens. The B-lymphoblastoid cDNA expression system can also be used to determine whether a chemical will be hazardous or toxic to humans. The most intriguing aspects of P450s are the occurrence of human genetic polymorphisms in P450 expression, which could be a risk factor for chemical carcinogenesis. The best-studied P450 genetic polymorphism is the debrisoquine/sparteine polymorphism which is due to mutant CYP2D6 alleles. Four mutant alleles have been characterized that account for most of the defective CYP2D6 genes in Caucasians. These can be detected by polymerase chain reaction assays.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2075589177 created "2016-06-24" @default.
• W2075589177 creator A5004680172 @default.
• W2075589177 creator A5073932699 @default.
• W2075589177 date "1992-11-01" @default.
• W2075589177 modified "2023-10-18" @default.
• W2075589177 title "Human cytochromes P450: evolution and cDNA-directed expression." @default.
• W2075589177 cites W1526269646 @default.
• W2075589177 cites W1540602043 @default.
• W2075589177 cites W1544140936 @default.
• W2075589177 cites W1584188206 @default.
• W2075589177 cites W1830202119 @default.
• W2075589177 cites W1923851271 @default.
• W2075589177 cites W1970001067 @default.
• W2075589177 cites W1970555747 @default.
• W2075589177 cites W1971398360 @default.
• W2075589177 cites W1973407453 @default.
• W2075589177 cites W1974993420 @default.
• W2075589177 cites W1979034152 @default.
• W2075589177 cites W1986498250 @default.
• W2075589177 cites W1990541549 @default.
• W2075589177 cites W1998883166 @default.
• W2075589177 cites W2007972960 @default.
• W2075589177 cites W2011267529 @default.
• W2075589177 cites W2012814689 @default.
• W2075589177 cites W2016556820 @default.
• W2075589177 cites W2024583045 @default.
• W2075589177 cites W2037289310 @default.
• W2075589177 cites W2042525065 @default.
• W2075589177 cites W2065516217 @default.
• W2075589177 cites W2071332031 @default.
• W2075589177 cites W2078724412 @default.
• W2075589177 cites W2082119404 @default.
• W2075589177 cites W2088524561 @default.
• W2075589177 cites W2092191147 @default.
• W2075589177 cites W2115717824 @default.
• W2075589177 cites W2169838870 @default.
• W2075589177 cites W2187622123 @default.
• W2075589177 cites W2274594089 @default.
• W2075589177 cites W2414900160 @default.
• W2075589177 cites W4229790662 @default.
• W2075589177 cites W15515081 @default.
• W2075589177 doi "https://doi.org/10.1289/ehp.929881" @default.
• W2075589177 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1519618" @default.
• W2075589177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1486867" @default.
• W2075589177 hasPublicationYear "1992" @default.
• W2075589177 type Work @default.
• W2075589177 sameAs 2075589177 @default.
• W2075589177 citedByCount "60" @default.
• W2075589177 countsByYear W20755891772012 @default.
• W2075589177 countsByYear W20755891772014 @default.
• W2075589177 countsByYear W20755891772016 @default.
• W2075589177 countsByYear W20755891772018 @default.
• W2075589177 countsByYear W20755891772019 @default.
• W2075589177 countsByYear W20755891772020 @default.
• W2075589177 countsByYear W20755891772021 @default.
• W2075589177 countsByYear W20755891772022 @default.
• W2075589177 countsByYear W20755891772023 @default.
• W2075589177 crossrefType "journal-article" @default.
• W2075589177 hasAuthorship W2075589177A5004680172 @default.
• W2075589177 hasAuthorship W2075589177A5073932699 @default.
• W2075589177 hasBestOaLocation W20755891771 @default.
• W2075589177 hasConcept C104317684 @default.
• W2075589177 hasConcept C114246631 @default.
• W2075589177 hasConcept C135763542 @default.
• W2075589177 hasConcept C143065580 @default.
• W2075589177 hasConcept C150194340 @default.
• W2075589177 hasConcept C180754005 @default.
• W2075589177 hasConcept C181199279 @default.
• W2075589177 hasConcept C187882448 @default.
• W2075589177 hasConcept C2777600422 @default.
• W2075589177 hasConcept C33664856 @default.
• W2075589177 hasConcept C526171541 @default.
• W2075589177 hasConcept C54355233 @default.
• W2075589177 hasConcept C55493867 @default.
• W2075589177 hasConcept C555283112 @default.
• W2075589177 hasConcept C86803240 @default.
• W2075589177 hasConceptScore W2075589177C104317684 @default.
• W2075589177 hasConceptScore W2075589177C114246631 @default.
• W2075589177 hasConceptScore W2075589177C135763542 @default.
• W2075589177 hasConceptScore W2075589177C143065580 @default.
• W2075589177 hasConceptScore W2075589177C150194340 @default.
• W2075589177 hasConceptScore W2075589177C180754005 @default.
• W2075589177 hasConceptScore W2075589177C181199279 @default.
• W2075589177 hasConceptScore W2075589177C187882448 @default.
• W2075589177 hasConceptScore W2075589177C2777600422 @default.
• W2075589177 hasConceptScore W2075589177C33664856 @default.
• W2075589177 hasConceptScore W2075589177C526171541 @default.
• W2075589177 hasConceptScore W2075589177C54355233 @default.
• W2075589177 hasConceptScore W2075589177C55493867 @default.
• W2075589177 hasConceptScore W2075589177C555283112 @default.
• W2075589177 hasConceptScore W2075589177C86803240 @default.
• W2075589177 hasLocation W20755891771 @default.
• W2075589177 hasLocation W20755891772 @default.
• W2075589177 hasLocation W20755891773 @default.
• W2075589177 hasLocation W20755891774 @default.
• W2075589177 hasOpenAccess W2075589177 @default.
• W2075589177 hasPrimaryLocation W20755891771 @default.

• next