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- W2075595885 endingPage "249" @default.
- W2075595885 startingPage "235" @default.
- W2075595885 abstract "Hepatitis B virus (HBV), the causative agent of B-type hepatitis in humans, is the type member of the Hepadnaviridae, hepatotropic DNA viruses that replicate via reverse transcription. Beyond long-established differences to retroviruses in gene expression and overall replication strategy newer work has uncovered additional distinctions in the mechanism of reverse transcription per se. These include protein-priming by the unique extra terminal protein domain of the reverse transcriptase (RT) utilizing an RNA hairpin for de novo initiation of first strand DNA synthesis, and the strict dependence of this process on cellular chaperones. Recent in vitro reconstitution systems enabled first biochemical insights into this multifactorial reaction, complemented by high resolution structural information on the RNA, though not yet the protein, level. Genetic approaches have revealed long-distance interactions in the nucleic acid templates as an important factor enabling the puzzling template switches required to produce the relaxed circular (RC) DNA found in infectious virions. Finally, the failure of even potent HBV RT inhibitors to eliminate nuclear covalently closed circular (ccc) DNA, the functional equivalent of integrated proviral DNA, has spurred a renewed interest in the mechanism of cccDNA generation. These new developments are in the focus of this review." @default.
- W2075595885 created "2016-06-24" @default.
- W2075595885 creator A5030576100 @default.
- W2075595885 date "2008-06-01" @default.
- W2075595885 modified "2023-10-06" @default.
- W2075595885 title "Hepatitis B viruses: Reverse transcription a different way" @default.
- W2075595885 cites W147468288 @default.
- W2075595885 cites W1501417543 @default.
- W2075595885 cites W1502882236 @default.
- W2075595885 cites W1524719295 @default.
- W2075595885 cites W1540134660 @default.
- W2075595885 cites W1551093031 @default.
- W2075595885 cites W1554644662 @default.
- W2075595885 cites W1556733566 @default.
- W2075595885 cites W1567952953 @default.
- W2075595885 cites W1568443657 @default.
- W2075595885 cites W1585835 @default.
- W2075595885 cites W1585930597 @default.
- W2075595885 cites W1594251072 @default.
- W2075595885 cites W1595414798 @default.
- W2075595885 cites W1598074241 @default.
- W2075595885 cites W1603287226 @default.
- W2075595885 cites W1631507265 @default.
- W2075595885 cites W1634116669 @default.
- W2075595885 cites W1805434135 @default.
- W2075595885 cites W1853569310 @default.
- W2075595885 cites W1894278338 @default.
- W2075595885 cites W1944388469 @default.
- W2075595885 cites W1965197241 @default.
- W2075595885 cites W1966416075 @default.
- W2075595885 cites W1967061843 @default.
- W2075595885 cites W1967159039 @default.
- W2075595885 cites W1968002980 @default.
- W2075595885 cites W1971141327 @default.
- W2075595885 cites W1972852906 @default.
- W2075595885 cites W1978323800 @default.
- W2075595885 cites W1978877699 @default.
- W2075595885 cites W1979730660 @default.
- W2075595885 cites W1981526509 @default.
- W2075595885 cites W1982255712 @default.
- W2075595885 cites W1982903295 @default.
- W2075595885 cites W1985860298 @default.
- W2075595885 cites W1987051472 @default.
- W2075595885 cites W1988209973 @default.
- W2075595885 cites W1997047331 @default.
- W2075595885 cites W1997709134 @default.
- W2075595885 cites W1998671948 @default.
- W2075595885 cites W2000594526 @default.
- W2075595885 cites W2001443927 @default.
- W2075595885 cites W2003440191 @default.
- W2075595885 cites W2004471053 @default.
- W2075595885 cites W2007278972 @default.
- W2075595885 cites W2007902841 @default.
- W2075595885 cites W2008287775 @default.
- W2075595885 cites W2011875501 @default.
- W2075595885 cites W2013528230 @default.
- W2075595885 cites W2015776048 @default.
- W2075595885 cites W2016032631 @default.
- W2075595885 cites W2017857849 @default.
- W2075595885 cites W2020879196 @default.
- W2075595885 cites W2022528017 @default.
- W2075595885 cites W2030140637 @default.
- W2075595885 cites W2031174462 @default.
- W2075595885 cites W2031579836 @default.
- W2075595885 cites W2038723467 @default.
- W2075595885 cites W2040925149 @default.
- W2075595885 cites W2042719661 @default.
- W2075595885 cites W2043892409 @default.
- W2075595885 cites W2044951291 @default.
- W2075595885 cites W2047443816 @default.
- W2075595885 cites W2051100798 @default.
- W2075595885 cites W2052553540 @default.
- W2075595885 cites W2052700689 @default.
- W2075595885 cites W2053352686 @default.
- W2075595885 cites W2054808517 @default.
- W2075595885 cites W2058376942 @default.
- W2075595885 cites W2059962010 @default.
- W2075595885 cites W2061239746 @default.
- W2075595885 cites W2061505027 @default.
- W2075595885 cites W2061605422 @default.
- W2075595885 cites W2062192098 @default.
- W2075595885 cites W2063295060 @default.
- W2075595885 cites W2066286787 @default.
- W2075595885 cites W2066684551 @default.
- W2075595885 cites W2067627888 @default.
- W2075595885 cites W2068330524 @default.
- W2075595885 cites W2069336380 @default.
- W2075595885 cites W2070144317 @default.
- W2075595885 cites W2070606532 @default.
- W2075595885 cites W2079139546 @default.
- W2075595885 cites W2089274167 @default.
- W2075595885 cites W2092038169 @default.
- W2075595885 cites W2101452651 @default.
- W2075595885 cites W2102293583 @default.
- W2075595885 cites W2103222099 @default.
- W2075595885 cites W2106477570 @default.
- W2075595885 cites W2106528530 @default.
- W2075595885 cites W2106591015 @default.