Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075603262> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2075603262 endingPage "591a" @default.
- W2075603262 startingPage "591a" @default.
- W2075603262 abstract "Almost all theoretical models of lipid “rafts” in the plasma membrane assume that the raft consists primarily of sphingomyelin (SM) and cholesterol which interact attractively, while the “sea” in which it floats consists mostly of phosphatidylcholine (PC). These are the three major components of the extracellular leaflet. However the most abundant components in the cytoplasmic leaflet are phosphatidylethanolamine (PE), phosphatidylserine (PS), and cholesterol. SM is present in only small concentrations. Hence any raft with SM as a major component in both leaves would be ineffective in the inner leaflet and not convey information from one side of the plasma membrane to the other. Recently I proposed a model of rafts in which they are represented as two-dimensional microemulsions, fluctuating heterogeneous regions, brought about by the coupling of curvature and concentration fluctuations. Because PE and cholesterol have very similar spontaneous curvatures which are quite different from that of PS, I propose that curvature fluctuations bring about a microemulsion, i.e. a raft, in the cytoplasmic leaf, consisting of PE and cholesterol, floating in a sea of PS. Due to the coupling of the two leaves, perhaps induced by the rapid exchange of cholesterol, the tendency of the inner leaf to form a microemulsion is conveyed to the extracellular leaf and brings about inhomogeneous regions there of which one is rich in SM and cholesterol and the other in PC. In this way, a raft would exist across the bilayer. Were the coupling of leaves due indeed to the exchange of cholesterol, one would envision a raft with cholesterol and SM in the outer leaf above cholesterol and PE in the inner leaf in a sea consisting of PC in the outer leaf and PS in the inner one." @default.
- W2075603262 created "2016-06-24" @default.
- W2075603262 creator A5001834892 @default.
- W2075603262 date "2013-01-01" @default.
- W2075603262 modified "2023-09-26" @default.
- W2075603262 title "A Raft for both Leaves of the Plasma Membrane" @default.
- W2075603262 doi "https://doi.org/10.1016/j.bpj.2012.11.3284" @default.
- W2075603262 hasPublicationYear "2013" @default.
- W2075603262 type Work @default.
- W2075603262 sameAs 2075603262 @default.
- W2075603262 citedByCount "0" @default.
- W2075603262 crossrefType "journal-article" @default.
- W2075603262 hasAuthorship W2075603262A5001834892 @default.
- W2075603262 hasBestOaLocation W20756032621 @default.
- W2075603262 hasConcept C12554922 @default.
- W2075603262 hasConcept C131584629 @default.
- W2075603262 hasConcept C15920480 @default.
- W2075603262 hasConcept C178790620 @default.
- W2075603262 hasConcept C185592680 @default.
- W2075603262 hasConcept C190062978 @default.
- W2075603262 hasConcept C191897082 @default.
- W2075603262 hasConcept C192157962 @default.
- W2075603262 hasConcept C192562407 @default.
- W2075603262 hasConcept C2776330855 @default.
- W2075603262 hasConcept C2778163477 @default.
- W2075603262 hasConcept C2778918659 @default.
- W2075603262 hasConcept C2779637612 @default.
- W2075603262 hasConcept C2781170229 @default.
- W2075603262 hasConcept C41625074 @default.
- W2075603262 hasConcept C521977710 @default.
- W2075603262 hasConcept C55493867 @default.
- W2075603262 hasConcept C61322309 @default.
- W2075603262 hasConcept C86803240 @default.
- W2075603262 hasConcept C9132879 @default.
- W2075603262 hasConcept C95444343 @default.
- W2075603262 hasConceptScore W2075603262C12554922 @default.
- W2075603262 hasConceptScore W2075603262C131584629 @default.
- W2075603262 hasConceptScore W2075603262C15920480 @default.
- W2075603262 hasConceptScore W2075603262C178790620 @default.
- W2075603262 hasConceptScore W2075603262C185592680 @default.
- W2075603262 hasConceptScore W2075603262C190062978 @default.
- W2075603262 hasConceptScore W2075603262C191897082 @default.
- W2075603262 hasConceptScore W2075603262C192157962 @default.
- W2075603262 hasConceptScore W2075603262C192562407 @default.
- W2075603262 hasConceptScore W2075603262C2776330855 @default.
- W2075603262 hasConceptScore W2075603262C2778163477 @default.
- W2075603262 hasConceptScore W2075603262C2778918659 @default.
- W2075603262 hasConceptScore W2075603262C2779637612 @default.
- W2075603262 hasConceptScore W2075603262C2781170229 @default.
- W2075603262 hasConceptScore W2075603262C41625074 @default.
- W2075603262 hasConceptScore W2075603262C521977710 @default.
- W2075603262 hasConceptScore W2075603262C55493867 @default.
- W2075603262 hasConceptScore W2075603262C61322309 @default.
- W2075603262 hasConceptScore W2075603262C86803240 @default.
- W2075603262 hasConceptScore W2075603262C9132879 @default.
- W2075603262 hasConceptScore W2075603262C95444343 @default.
- W2075603262 hasIssue "2" @default.
- W2075603262 hasLocation W20756032621 @default.
- W2075603262 hasOpenAccess W2075603262 @default.
- W2075603262 hasPrimaryLocation W20756032621 @default.
- W2075603262 hasRelatedWork W1995873562 @default.
- W2075603262 hasRelatedWork W2076320571 @default.
- W2075603262 hasRelatedWork W2076546515 @default.
- W2075603262 hasRelatedWork W2085574886 @default.
- W2075603262 hasRelatedWork W2103987812 @default.
- W2075603262 hasRelatedWork W2315535273 @default.
- W2075603262 hasRelatedWork W2460195908 @default.
- W2075603262 hasRelatedWork W420565968 @default.
- W2075603262 hasRelatedWork W4298058407 @default.
- W2075603262 hasRelatedWork W1762118 @default.
- W2075603262 hasVolume "104" @default.
- W2075603262 isParatext "false" @default.
- W2075603262 isRetracted "false" @default.
- W2075603262 magId "2075603262" @default.
- W2075603262 workType "article" @default.