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- W2075617812 abstract "Procedures were described for the study of the binding of γ-aminobutyric acid (γABA)-1-14C, which takes place with various brain preparations but not in similar preparations of several other tissues tested. All the binding activity, which does not require energy and is nonenzymatic, was found in the sedimentable fractions of sucrose homogenates of mouse brain, largely in the “mitochondrial” and “microsomal” fractions. The pH optimum for binding was found to be approximately between 7.3 and 7.5. γABA binding by the preparation was shown to be Na+-dependent. There is a considerable degree of specificity in the structural requirements for yABA binding, and even minor variations in structure give substances with less affinity than γABA for the binding substance of structures. Experiments with surface-active materials and with sulfhydryl reagents led to the suggestion that the binding capacity is associated with osmotically sensitive macromolecular structural elements, among the components of which may be proteins with reactive sulfhydryl groups. Two antihistamines, two phenothiazine derivatives, and imipramine and desmethylimipramine were found to inhibit γABA binding. Several other pharmacologically active substances which were tested were found to be without effect." @default.
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- W2075617812 date "1963-05-01" @default.
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- W2075617812 title "Binding of γ-aminobutyric acid by mouse brain preparations" @default.
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- W2075617812 doi "https://doi.org/10.1016/0006-2952(63)90228-4" @default.
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