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- W2075618997 abstract "ObjectiveTo determine whether the CAG repeat length of the androgen receptor (AR) gene contributes to individual differences in the susceptibility to the development of polycystic ovary syndrome (PCOS).DesignRetrospective case-control study.SettingUniversity-based clinic.Patient(s)One hundred six nondiabetic women with PCOS and 112 nonhirsute fertile controls.Intervention(s)Androgen receptor gene CAG repeat length was analyzed in women with PCOS and their controls.Main Outcome Measure(s)Androgen receptor gene CAG repeat length in both groups.Result(s)The mean CAGn was 21.5 repeats in both groups (NS; t-test). Furthermore, when the CAGn lengths were divided into three categories (CAGn ≤18, 19–24, ≥25), the distribution was similar in both groups (NS; χ2 test). However, all five women carrying ≤15 CAG repeats belonged to the PCOS group. In the PCOS group, CAGn did not correlate with body mass index or serum testosterone concentration.Conclusion(s)Androgen receptor CAGn is not a major determinant of PCOS. However, it may be a significant modulator of androgen-related diseases in some individuals. To determine whether the CAG repeat length of the androgen receptor (AR) gene contributes to individual differences in the susceptibility to the development of polycystic ovary syndrome (PCOS). Retrospective case-control study. University-based clinic. One hundred six nondiabetic women with PCOS and 112 nonhirsute fertile controls. Androgen receptor gene CAG repeat length was analyzed in women with PCOS and their controls. Androgen receptor gene CAG repeat length in both groups. The mean CAGn was 21.5 repeats in both groups (NS; t-test). Furthermore, when the CAGn lengths were divided into three categories (CAGn ≤18, 19–24, ≥25), the distribution was similar in both groups (NS; χ2 test). However, all five women carrying ≤15 CAG repeats belonged to the PCOS group. In the PCOS group, CAGn did not correlate with body mass index or serum testosterone concentration. Androgen receptor CAGn is not a major determinant of PCOS. However, it may be a significant modulator of androgen-related diseases in some individuals." @default.
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- W2075618997 date "2005-06-01" @default.
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- W2075618997 title "Androgen receptor gene CAG length polymorphism in women with polycystic ovary syndrome" @default.
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- W2075618997 doi "https://doi.org/10.1016/j.fertnstert.2004.11.080" @default.
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