FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075625968> ?p ?o ?g. }

• W2075625968 endingPage "124" @default.
• W2075625968 startingPage "118" @default.
• W2075625968 abstract "1. The effects of endotoxaemia on coronary vasodilator responses to bradykinin (BK), sodium nitroprusside (SNP) and nicardipine were investigated in the rat isolated heart perfused at constant flow ex vivo. 2. Dose-dependent reductions in coronary perfusion pressure reaching a maximum of 56+/-3 and 57+/-5 mmHg were observed for BK and SNP respectively. The BK response was biphasic, consisting of a rapid dilator response that was insensitive to N(G)nitro-L-arginine methyl ester (L-NAME, 0.1 mM) and a second slower component whose duration was attenuated by L-NAME. 3. Hearts obtained from rats treated with endotoxin (2.5 mg kg(-1), i.p.) for 2 or 6 h had increased basal coronary perfusion pressure and reduced vasodilator responses to BK or SNP. Dilator responses to nicardipine were not affected by endotoxin treatment. In vitro perfusion of hearts from endotoxin-treated rats with L-NAME (0.1 mM) restored SNP responses to control values. 4. Treatment with dexamethasone (1 mg kg(-1)), 1 h before endotoxin did not alter the endotoxin-induced impairment of dilator responses to BK or SNP. 5. These results show that coronary microvascular responses are altered following endotoxin exposure. Endotoxin results in increased coronary microvascular tone despite induction of NO synthase and inhibits the dilator response to BK and SNP, vasodilators that act via the release of NO. Responses to SNP in endotoxin-treated hearts were restored to control values in the presence of L-NAME suggesting that enhanced endogenous NO synthesis might saturate guanylate cyclase resulting in reduced response to NO donors. The reduced response to vasodilators and increased coronary resistance might be important in determining the response of the coronary circulation to systemic inflammation and infection." @default.
• W2075625968 created "2016-06-24" @default.
• W2075625968 creator A5020788754 @default.
• W2075625968 creator A5056664985 @default.
• W2075625968 creator A5056800378 @default.
• W2075625968 creator A5073267685 @default.
• W2075625968 date "2000-05-01" @default.
• W2075625968 modified "2023-09-26" @default.
• W2075625968 title "Impaired vascular sensitivity to nitric oxide in the coronary microvasculature after endotoxaemia" @default.
• W2075625968 cites W1959667136 @default.
• W2075625968 cites W1975576863 @default.
• W2075625968 cites W1982947678 @default.
• W2075625968 cites W1986947248 @default.
• W2075625968 cites W1990157237 @default.
• W2075625968 cites W2001206634 @default.
• W2075625968 cites W2002383988 @default.
• W2075625968 cites W2003869754 @default.
• W2075625968 cites W2012364099 @default.
• W2075625968 cites W2019951936 @default.
• W2075625968 cites W2021324668 @default.
• W2075625968 cites W2029336339 @default.
• W2075625968 cites W2029583951 @default.
• W2075625968 cites W2031533866 @default.
• W2075625968 cites W2043701377 @default.
• W2075625968 cites W2049048252 @default.
• W2075625968 cites W2051693516 @default.
• W2075625968 cites W2055814183 @default.
• W2075625968 cites W2058533505 @default.
• W2075625968 cites W2067338751 @default.
• W2075625968 cites W2069374431 @default.
• W2075625968 cites W2076362512 @default.
• W2075625968 cites W2078840294 @default.
• W2075625968 cites W2081546029 @default.
• W2075625968 cites W2082679020 @default.
• W2075625968 cites W2086202280 @default.
• W2075625968 cites W2101766406 @default.
• W2075625968 cites W2146668042 @default.
• W2075625968 cites W2157326323 @default.
• W2075625968 cites W2158387263 @default.
• W2075625968 cites W2163738693 @default.
• W2075625968 cites W2175415106 @default.
• W2075625968 cites W22105626 @default.
• W2075625968 cites W2279400880 @default.
• W2075625968 cites W2318065544 @default.
• W2075625968 cites W2335973780 @default.
• W2075625968 cites W2401983899 @default.
• W2075625968 cites W2411190762 @default.
• W2075625968 cites W2415945904 @default.
• W2075625968 cites W2410488769 @default.
• W2075625968 doi "https://doi.org/10.1038/sj.bjp.0703267" @default.
• W2075625968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1572031" @default.
• W2075625968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10781006" @default.
• W2075625968 hasPublicationYear "2000" @default.
• W2075625968 type Work @default.
• W2075625968 sameAs 2075625968 @default.
• W2075625968 citedByCount "17" @default.
• W2075625968 countsByYear W20756259682012 @default.
• W2075625968 countsByYear W20756259682014 @default.
• W2075625968 countsByYear W20756259682015 @default.
• W2075625968 countsByYear W20756259682020 @default.
• W2075625968 crossrefType "journal-article" @default.
• W2075625968 hasAuthorship W2075625968A5020788754 @default.
• W2075625968 hasAuthorship W2075625968A5056664985 @default.
• W2075625968 hasAuthorship W2075625968A5056800378 @default.
• W2075625968 hasAuthorship W2075625968A5073267685 @default.
• W2075625968 hasBestOaLocation W20756259682 @default.
• W2075625968 hasConcept C120770815 @default.
• W2075625968 hasConcept C126322002 @default.
• W2075625968 hasConcept C134018914 @default.
• W2075625968 hasConcept C146957229 @default.
• W2075625968 hasConcept C170493617 @default.
• W2075625968 hasConcept C185592680 @default.
• W2075625968 hasConcept C2777032099 @default.
• W2075625968 hasConcept C2777055891 @default.
• W2075625968 hasConcept C2777862461 @default.
• W2075625968 hasConcept C2778043224 @default.
• W2075625968 hasConcept C2778165595 @default.
• W2075625968 hasConcept C2778827303 @default.
• W2075625968 hasConcept C2779591629 @default.
• W2075625968 hasConcept C2779610285 @default.
• W2075625968 hasConcept C3020139451 @default.
• W2075625968 hasConcept C42219234 @default.
• W2075625968 hasConcept C519581460 @default.
• W2075625968 hasConcept C71924100 @default.
• W2075625968 hasConcept C84393581 @default.
• W2075625968 hasConcept C98274493 @default.
• W2075625968 hasConceptScore W2075625968C120770815 @default.
• W2075625968 hasConceptScore W2075625968C126322002 @default.
• W2075625968 hasConceptScore W2075625968C134018914 @default.
• W2075625968 hasConceptScore W2075625968C146957229 @default.
• W2075625968 hasConceptScore W2075625968C170493617 @default.
• W2075625968 hasConceptScore W2075625968C185592680 @default.
• W2075625968 hasConceptScore W2075625968C2777032099 @default.
• W2075625968 hasConceptScore W2075625968C2777055891 @default.
• W2075625968 hasConceptScore W2075625968C2777862461 @default.
• W2075625968 hasConceptScore W2075625968C2778043224 @default.
• W2075625968 hasConceptScore W2075625968C2778165595 @default.
• W2075625968 hasConceptScore W2075625968C2778827303 @default.

• next