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- W2075639695 abstract "A novel series of 2-(3-pyridyl)alkoxy-5-aryltetrahydrofuran PAF antagonists has been identified and the effect of variation of the alkoxy chain length, aryl substitution and stereochemistry about the tetrahydrofuran ring studied. The optimal compound, cis-(±)-2-(3-(3-pyridyl)propanoxy)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (27a), inhibits 3H]-PAF receptor binding to washed human platelet membranes with an IC50 value of 100 nM." @default.
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- W2075639695 date "1993-08-01" @default.
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- W2075639695 title "Cyclic ether acetal platelet activating factor (PAF) receptor antagonists I: 3-pyridyl derivatives" @default.
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