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• W2075639787 abstract "Abstract A very concise synthesis of a potent KDR kinase inhibitor 1 is described. The synthesis features an exceedingly efficient one-pot preparation of the aminothiazole 6 followed by Pd–Xantphos catalyzed cross-coupling with chloropyridine aldehyde 11 . Reductive amination of the resulting aldehyde 10 with the piperazine fragment 9 afforded the final product." @default.
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• W2075639787 date "2006-02-01" @default.
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• W2075639787 title "A very concise synthesis of a potent N-(1,3-thiazol-2-yl)pyridin-2-amine KDR kinase inhibitor" @default.
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• W2075639787 doi "https://doi.org/10.1016/j.tet.2005.10.081" @default.
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