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- W2075653203 abstract "As a group of disorders, autoimmunity ranks as the third most prevalent cause of morbidity and mortality in the Western World. However, the etiology of most autoimmune diseases remains unknown. Although genetic linkage studies support a critical underlying role for genetics, the geographic distribution of these disorders as well as the low concordance rates in monozygotic twins suggest that a combination of other factors including environmental ones are involved. Virus infection is a primary factor that has been implicated in the initiation of autoimmune disease. Infection triggers a robust and usually well-coordinated immune response that is critical for viral clearance. However, in some instances, immune regulatory mechanisms may falter, culminating in the breakdown of self-tolerance, resulting in immune-mediated attack directed against both viral and self-antigens. Traditionally, cross-reactive T-cell recognition, known as molecular mimicry, as well as bystander T-cell activation, culminating in epitope spreading, have been the predominant mechanisms elucidated through which infection may culminate in an T-cell-mediated autoimmune response. However, other hypotheses including virus-induced decoy of the immune system also warrant discussion in regard to their potential for triggering autoimmunity. In this review, we discuss the mechanisms by which virus infection and antiviral immunity contribute to the development of autoimmunity." @default.
- W2075653203 created "2016-06-24" @default.
- W2075653203 creator A5033876610 @default.
- W2075653203 creator A5050455996 @default.
- W2075653203 creator A5077468407 @default.
- W2075653203 creator A5082489300 @default.
- W2075653203 date "2013-08-15" @default.
- W2075653203 modified "2023-10-14" @default.
- W2075653203 title "Virus infection, antiviral immunity, and autoimmunity" @default.
- W2075653203 cites W113187801 @default.
- W2075653203 cites W1486809959 @default.
- W2075653203 cites W1528365943 @default.
- W2075653203 cites W1532139449 @default.
- W2075653203 cites W154308685 @default.
- W2075653203 cites W1551639690 @default.
- W2075653203 cites W1554180636 @default.
- W2075653203 cites W1557299246 @default.
- W2075653203 cites W1558647135 @default.
- W2075653203 cites W1574158946 @default.
- W2075653203 cites W1578954095 @default.
- W2075653203 cites W1598846281 @default.
- W2075653203 cites W1630776565 @default.
- W2075653203 cites W1650999727 @default.
- W2075653203 cites W167368693 @default.
- W2075653203 cites W1777541923 @default.
- W2075653203 cites W1782133112 @default.
- W2075653203 cites W1798317578 @default.
- W2075653203 cites W1818847823 @default.
- W2075653203 cites W1860214796 @default.
- W2075653203 cites W1963639770 @default.
- W2075653203 cites W1964133627 @default.
- W2075653203 cites W1966551297 @default.
- W2075653203 cites W1968961493 @default.
- W2075653203 cites W1975357271 @default.
- W2075653203 cites W1977824948 @default.
- W2075653203 cites W1977891415 @default.
- W2075653203 cites W1978883524 @default.
- W2075653203 cites W1979401674 @default.
- W2075653203 cites W1981688486 @default.
- W2075653203 cites W1991325002 @default.
- W2075653203 cites W1992802035 @default.
- W2075653203 cites W1995201985 @default.
- W2075653203 cites W1997114065 @default.
- W2075653203 cites W1998041024 @default.
- W2075653203 cites W1998258994 @default.
- W2075653203 cites W1998316565 @default.
- W2075653203 cites W1999136843 @default.
- W2075653203 cites W2000372703 @default.
- W2075653203 cites W2000795045 @default.
- W2075653203 cites W2003877200 @default.
- W2075653203 cites W2003961230 @default.
- W2075653203 cites W2005603236 @default.
- W2075653203 cites W2011275029 @default.
- W2075653203 cites W2011386800 @default.
- W2075653203 cites W2011450045 @default.
- W2075653203 cites W2012177273 @default.
- W2075653203 cites W2015272984 @default.
- W2075653203 cites W2016333231 @default.
- W2075653203 cites W2018027744 @default.
- W2075653203 cites W2019194771 @default.
- W2075653203 cites W2020996714 @default.
- W2075653203 cites W2021951643 @default.
- W2075653203 cites W2022649266 @default.
- W2075653203 cites W2030061181 @default.
- W2075653203 cites W2031185538 @default.
- W2075653203 cites W2032432537 @default.
- W2075653203 cites W2034860726 @default.
- W2075653203 cites W2035336072 @default.
- W2075653203 cites W2036070626 @default.
- W2075653203 cites W2037248944 @default.
- W2075653203 cites W2038768395 @default.
- W2075653203 cites W2039328905 @default.
- W2075653203 cites W2041654740 @default.
- W2075653203 cites W2041711928 @default.
- W2075653203 cites W2043976521 @default.
- W2075653203 cites W2044400894 @default.
- W2075653203 cites W2045900375 @default.
- W2075653203 cites W2046749316 @default.
- W2075653203 cites W2047450424 @default.
- W2075653203 cites W2050643697 @default.
- W2075653203 cites W2051888431 @default.
- W2075653203 cites W2057328452 @default.
- W2075653203 cites W2057817955 @default.
- W2075653203 cites W2060509927 @default.
- W2075653203 cites W2060656407 @default.
- W2075653203 cites W2064460845 @default.
- W2075653203 cites W2067287812 @default.
- W2075653203 cites W2072921751 @default.
- W2075653203 cites W2073279878 @default.
- W2075653203 cites W2074051982 @default.
- W2075653203 cites W2074136122 @default.
- W2075653203 cites W2074484064 @default.
- W2075653203 cites W2074835752 @default.
- W2075653203 cites W2076923050 @default.
- W2075653203 cites W2078699094 @default.
- W2075653203 cites W2081060219 @default.
- W2075653203 cites W2081632246 @default.
- W2075653203 cites W2083190337 @default.