Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075681930> ?p ?o ?g. }
- W2075681930 endingPage "200" @default.
- W2075681930 startingPage "195" @default.
- W2075681930 abstract "A creatinine metabolite, 5-hydroxy-1-methylhydantoin (HMH: NZ-419), a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. In the current study, we demonstrate that HMH modulates the effects of glucose and bradykinin (BK) in vascular smooth muscle cell (VSMC). HMH a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. HMH inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that HMH may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties." @default.
- W2075681930 created "2016-06-24" @default.
- W2075681930 creator A5022546262 @default.
- W2075681930 creator A5036030305 @default.
- W2075681930 creator A5057553024 @default.
- W2075681930 creator A5057910930 @default.
- W2075681930 date "2014-03-18" @default.
- W2075681930 modified "2023-10-16" @default.
- W2075681930 title "Creatinine metabolite, HMH (5-hydroxy-1-methylhydantoin; NZ-419), modulates bradykinin-induced changes in vascular smooth muscle cells" @default.
- W2075681930 cites W1543291357 @default.
- W2075681930 cites W1775749144 @default.
- W2075681930 cites W1899552864 @default.
- W2075681930 cites W1968675109 @default.
- W2075681930 cites W1970222518 @default.
- W2075681930 cites W1973720522 @default.
- W2075681930 cites W1975085088 @default.
- W2075681930 cites W1976921037 @default.
- W2075681930 cites W1977798903 @default.
- W2075681930 cites W1978639717 @default.
- W2075681930 cites W1989839012 @default.
- W2075681930 cites W1990581298 @default.
- W2075681930 cites W1993765215 @default.
- W2075681930 cites W1999211167 @default.
- W2075681930 cites W2001870404 @default.
- W2075681930 cites W2007175840 @default.
- W2075681930 cites W2021091148 @default.
- W2075681930 cites W2024551515 @default.
- W2075681930 cites W2030593202 @default.
- W2075681930 cites W2041075406 @default.
- W2075681930 cites W2055530781 @default.
- W2075681930 cites W2057062821 @default.
- W2075681930 cites W2061523453 @default.
- W2075681930 cites W2063198212 @default.
- W2075681930 cites W2085102477 @default.
- W2075681930 cites W2090672150 @default.
- W2075681930 cites W2099558249 @default.
- W2075681930 cites W2103865604 @default.
- W2075681930 cites W2108849150 @default.
- W2075681930 cites W2114927504 @default.
- W2075681930 cites W2119298023 @default.
- W2075681930 cites W2120494611 @default.
- W2075681930 cites W2122057254 @default.
- W2075681930 cites W2131863327 @default.
- W2075681930 cites W2132679962 @default.
- W2075681930 cites W2134796435 @default.
- W2075681930 cites W2137570167 @default.
- W2075681930 cites W2142070428 @default.
- W2075681930 cites W2151534825 @default.
- W2075681930 cites W2161547170 @default.
- W2075681930 cites W2165674845 @default.
- W2075681930 cites W2175687760 @default.
- W2075681930 cites W2182463865 @default.
- W2075681930 cites W2280301353 @default.
- W2075681930 cites W2323685667 @default.
- W2075681930 cites W2402304726 @default.
- W2075681930 cites W2408917168 @default.
- W2075681930 cites W4251444321 @default.
- W2075681930 doi "https://doi.org/10.3109/10799893.2013.876039" @default.
- W2075681930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24641698" @default.
- W2075681930 hasPublicationYear "2014" @default.
- W2075681930 type Work @default.
- W2075681930 sameAs 2075681930 @default.
- W2075681930 citedByCount "3" @default.
- W2075681930 countsByYear W20756819302017 @default.
- W2075681930 countsByYear W20756819302020 @default.
- W2075681930 crossrefType "journal-article" @default.
- W2075681930 hasAuthorship W2075681930A5022546262 @default.
- W2075681930 hasAuthorship W2075681930A5036030305 @default.
- W2075681930 hasAuthorship W2075681930A5057553024 @default.
- W2075681930 hasAuthorship W2075681930A5057910930 @default.
- W2075681930 hasConcept C126322002 @default.
- W2075681930 hasConcept C134018914 @default.
- W2075681930 hasConcept C170493617 @default.
- W2075681930 hasConcept C185592680 @default.
- W2075681930 hasConcept C24998067 @default.
- W2075681930 hasConcept C2775960820 @default.
- W2075681930 hasConcept C2779395532 @default.
- W2075681930 hasConcept C2779591629 @default.
- W2075681930 hasConcept C2780631158 @default.
- W2075681930 hasConcept C2992686903 @default.
- W2075681930 hasConcept C71924100 @default.
- W2075681930 hasConcept C86803240 @default.
- W2075681930 hasConceptScore W2075681930C126322002 @default.
- W2075681930 hasConceptScore W2075681930C134018914 @default.
- W2075681930 hasConceptScore W2075681930C170493617 @default.
- W2075681930 hasConceptScore W2075681930C185592680 @default.
- W2075681930 hasConceptScore W2075681930C24998067 @default.
- W2075681930 hasConceptScore W2075681930C2775960820 @default.
- W2075681930 hasConceptScore W2075681930C2779395532 @default.
- W2075681930 hasConceptScore W2075681930C2779591629 @default.
- W2075681930 hasConceptScore W2075681930C2780631158 @default.
- W2075681930 hasConceptScore W2075681930C2992686903 @default.
- W2075681930 hasConceptScore W2075681930C71924100 @default.
- W2075681930 hasConceptScore W2075681930C86803240 @default.
- W2075681930 hasIssue "3" @default.
- W2075681930 hasLocation W20756819301 @default.
- W2075681930 hasLocation W20756819302 @default.
- W2075681930 hasOpenAccess W2075681930 @default.