FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075692817> ?p ?o ?g. }

• W2075692817 endingPage "e75950" @default.
• W2075692817 startingPage "e75950" @default.
• W2075692817 abstract "Background Ischemia-reperfusion (I/R) injury is associated with intestinal microbial dysbiosis. The “gut-liver axis” closely links gut function and liver function in health and disease. Ischemic preconditioning (IPC) has been proven to reduce I/R injury in the surgery. This study aims to explore the effect of IPC on intestinal microbiota and to analyze characteristics of microbial structure shift following liver transplantation (LT). Methods The LT animal models of liver and gut IPC were established. Hepatic graft function was assessed by histology and serum ALT/AST. Intestinal barrier function was evaluated by mucosal ultrastructure, serum endotoxin, bacterial translocation, fecal sIgA content and serum TNF-α. Intestinal bacterial populations were determined by quantitative PCR. Microbial composition was characterized by DGGE and specific bacterial species were determined by sequence analysis. Principal Findings Liver IPC improved hepatic graft function expressed as ameliorated graft structure and reduced ALT/AST levels. After administration of liver IPC, intestinal mucosal ultrastructure improved, serum endotoxin and bacterial translocation mildly decreased, fecal sIgA content increased, and serum TNF-α decreased. Moreover, liver IPC promoted microbial restorations mainly through restoring Bifidobacterium spp., Clostridium clusters XI and Clostridium cluster XIVab on bacterial genus level. DGGE profiles indicated that liver IPC increased microbial diversity and species richness, and cluster analysis demonstrated that microbial structures were similar and clustered together between the NC group and Liver-IPC group. Furthermore, the phylogenetic tree of band sequences showed key bacteria corresponding to 10 key band classes of microbial structure shift induced by liver IPC, most of which were assigned to Bacteroidetes phylum. Conclusion Liver IPC cannot only improve hepatic graft function and intestinal barrier function, but also promote restorations of intestinal microbiota following LT, which may further benefit hepatic graft by positive feedback of the “gut-liver axis”." @default.
• W2075692817 created "2016-06-24" @default.
• W2075692817 creator A5003281764 @default.
• W2075692817 creator A5004666576 @default.
• W2075692817 creator A5016628945 @default.
• W2075692817 creator A5017119373 @default.
• W2075692817 creator A5023795154 @default.
• W2075692817 creator A5024421837 @default.
• W2075692817 creator A5025283381 @default.
• W2075692817 creator A5027334447 @default.
• W2075692817 creator A5043418555 @default.
• W2075692817 creator A5044301848 @default.
• W2075692817 creator A5062435881 @default.
• W2075692817 date "2013-10-02" @default.
• W2075692817 modified "2023-09-22" @default.
• W2075692817 title "Liver Ischemic Preconditioning (IPC) Improves Intestinal Microbiota Following Liver Transplantation in Rats through 16s rDNA-Based Analysis of Microbial Structure Shift" @default.
• W2075692817 cites W1507338356 @default.
• W2075692817 cites W162447880 @default.
• W2075692817 cites W1965495044 @default.
• W2075692817 cites W1972686367 @default.
• W2075692817 cites W1980914602 @default.
• W2075692817 cites W2009147223 @default.
• W2075692817 cites W2010563061 @default.
• W2075692817 cites W2011338213 @default.
• W2075692817 cites W2046073811 @default.
• W2075692817 cites W2051567523 @default.
• W2075692817 cites W2055548599 @default.
• W2075692817 cites W2059923680 @default.
• W2075692817 cites W2064329624 @default.
• W2075692817 cites W2068670069 @default.
• W2075692817 cites W2070413937 @default.
• W2075692817 cites W2074535574 @default.
• W2075692817 cites W2080646285 @default.
• W2075692817 cites W2084850564 @default.
• W2075692817 cites W2085153086 @default.
• W2075692817 cites W2089699689 @default.
• W2075692817 cites W2090781255 @default.
• W2075692817 cites W2099360240 @default.
• W2075692817 cites W2120459847 @default.
• W2075692817 cites W2132406938 @default.
• W2075692817 cites W2145336165 @default.
• W2075692817 cites W2146217294 @default.
• W2075692817 cites W2169330513 @default.
• W2075692817 cites W2170038590 @default.
• W2075692817 cites W2322026859 @default.
• W2075692817 cites W2343221002 @default.
• W2075692817 cites W3206482953 @default.
• W2075692817 doi "https://doi.org/10.1371/journal.pone.0075950" @default.
• W2075692817 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3788797" @default.
• W2075692817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24098410" @default.
• W2075692817 hasPublicationYear "2013" @default.
• W2075692817 type Work @default.
• W2075692817 sameAs 2075692817 @default.
• W2075692817 citedByCount "41" @default.
• W2075692817 countsByYear W20756928172014 @default.
• W2075692817 countsByYear W20756928172015 @default.
• W2075692817 countsByYear W20756928172016 @default.
• W2075692817 countsByYear W20756928172017 @default.
• W2075692817 countsByYear W20756928172018 @default.
• W2075692817 countsByYear W20756928172019 @default.
• W2075692817 countsByYear W20756928172020 @default.
• W2075692817 countsByYear W20756928172021 @default.
• W2075692817 countsByYear W20756928172022 @default.
• W2075692817 countsByYear W20756928172023 @default.
• W2075692817 crossrefType "journal-article" @default.
• W2075692817 hasAuthorship W2075692817A5003281764 @default.
• W2075692817 hasAuthorship W2075692817A5004666576 @default.
• W2075692817 hasAuthorship W2075692817A5016628945 @default.
• W2075692817 hasAuthorship W2075692817A5017119373 @default.
• W2075692817 hasAuthorship W2075692817A5023795154 @default.
• W2075692817 hasAuthorship W2075692817A5024421837 @default.
• W2075692817 hasAuthorship W2075692817A5025283381 @default.
• W2075692817 hasAuthorship W2075692817A5027334447 @default.
• W2075692817 hasAuthorship W2075692817A5043418555 @default.
• W2075692817 hasAuthorship W2075692817A5044301848 @default.
• W2075692817 hasAuthorship W2075692817A5062435881 @default.
• W2075692817 hasBestOaLocation W20756928171 @default.
• W2075692817 hasConcept C126322002 @default.
• W2075692817 hasConcept C203014093 @default.
• W2075692817 hasConcept C2777165150 @default.
• W2075692817 hasConcept C2777385719 @default.
• W2075692817 hasConcept C2779609443 @default.
• W2075692817 hasConcept C2911091166 @default.
• W2075692817 hasConcept C42062724 @default.
• W2075692817 hasConcept C523546767 @default.
• W2075692817 hasConcept C539455810 @default.
• W2075692817 hasConcept C54355233 @default.
• W2075692817 hasConcept C61716771 @default.
• W2075692817 hasConcept C71924100 @default.
• W2075692817 hasConcept C86803240 @default.
• W2075692817 hasConcept C89423630 @default.
• W2075692817 hasConceptScore W2075692817C126322002 @default.
• W2075692817 hasConceptScore W2075692817C203014093 @default.
• W2075692817 hasConceptScore W2075692817C2777165150 @default.
• W2075692817 hasConceptScore W2075692817C2777385719 @default.
• W2075692817 hasConceptScore W2075692817C2779609443 @default.
• W2075692817 hasConceptScore W2075692817C2911091166 @default.
• W2075692817 hasConceptScore W2075692817C42062724 @default.

• next