Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075694598> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2075694598 abstract "The effects of ethanol on the production of oxygen-derived free radicals by neutrophils are controversial. Osmolarity-mediated alteration of cell volume appears to be an important mechanism for regulating neutrophil activity. We investigated in neutrophils from healthy volunteers the effect of isotonic/hypertonic ethanol on both chemiluminescence amplified by a Cypridina luciferin analog in response to N-formyl-Met-Lue-Phe and cell volume measured with a Coulter counter. Both isotonic and hypertonic ethanol significantly decreased chemiluminescence in a dose-dependent manner. Isotonic ethanol produced a greater magnitude of inhibition than hypertonic ethanol (P<0.01). Another permeable molecule, urea, and hypotonic solution had the same effects on chemiluminescence. Isotonic and hypertonic ethanol caused a prompt cell expansion and shrinking, respectively. On the other hand, isotonic sucrose, an impermeable molecule, was ineffective in both chemiluminescence and cell volume changes. These data suggest that isotonic ethanol inhibits the superoxide anion production by inducing cell expansion probably due to increased intracellular osmotic pressure caused by rapid ethanol permeation through the plasmalemma. This impaired neutrophil function may, in some part, contribute to the susceptibility to infection in alcoholics." @default.
- W2075694598 created "2016-06-24" @default.
- W2075694598 creator A5000776443 @default.
- W2075694598 creator A5004878380 @default.
- W2075694598 creator A5086416459 @default.
- W2075694598 date "1998-09-01" @default.
- W2075694598 modified "2023-09-27" @default.
- W2075694598 title "Isotonic ethanol inhibits the generation of superoxide anion in neutrophils by inducing cell expansion" @default.
- W2075694598 cites W1618550443 @default.
- W2075694598 cites W1629188285 @default.
- W2075694598 cites W1963568896 @default.
- W2075694598 cites W1987660182 @default.
- W2075694598 cites W1991336686 @default.
- W2075694598 cites W1996941291 @default.
- W2075694598 cites W1999909149 @default.
- W2075694598 cites W2000874667 @default.
- W2075694598 cites W2014563978 @default.
- W2075694598 cites W2023122744 @default.
- W2075694598 cites W2030524261 @default.
- W2075694598 cites W2050472328 @default.
- W2075694598 cites W2053658854 @default.
- W2075694598 cites W2056892622 @default.
- W2075694598 cites W2062209757 @default.
- W2075694598 cites W2064916353 @default.
- W2075694598 cites W2071295383 @default.
- W2075694598 cites W2082382987 @default.
- W2075694598 cites W2082530695 @default.
- W2075694598 cites W2092259337 @default.
- W2075694598 cites W2107073126 @default.
- W2075694598 cites W2169862872 @default.
- W2075694598 cites W2170604178 @default.
- W2075694598 cites W2239119657 @default.
- W2075694598 cites W2239705930 @default.
- W2075694598 cites W2431782222 @default.
- W2075694598 cites W4235546503 @default.
- W2075694598 cites W4241553305 @default.
- W2075694598 cites W87456843 @default.
- W2075694598 doi "https://doi.org/10.1016/s0024-3205(98)00396-8" @default.
- W2075694598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9768870" @default.
- W2075694598 hasPublicationYear "1998" @default.
- W2075694598 type Work @default.
- W2075694598 sameAs 2075694598 @default.
- W2075694598 citedByCount "3" @default.
- W2075694598 countsByYear W20756945982013 @default.
- W2075694598 crossrefType "journal-article" @default.
- W2075694598 hasAuthorship W2075694598A5000776443 @default.
- W2075694598 hasAuthorship W2075694598A5004878380 @default.
- W2075694598 hasAuthorship W2075694598A5086416459 @default.
- W2075694598 hasConcept C117277713 @default.
- W2075694598 hasConcept C12554922 @default.
- W2075694598 hasConcept C129900496 @default.
- W2075694598 hasConcept C145802702 @default.
- W2075694598 hasConcept C181199279 @default.
- W2075694598 hasConcept C185592680 @default.
- W2075694598 hasConcept C2780161600 @default.
- W2075694598 hasConcept C2780795997 @default.
- W2075694598 hasConcept C28406088 @default.
- W2075694598 hasConcept C43617362 @default.
- W2075694598 hasConcept C55493867 @default.
- W2075694598 hasConcept C79879829 @default.
- W2075694598 hasConcept C86803240 @default.
- W2075694598 hasConcept C9603476 @default.
- W2075694598 hasConceptScore W2075694598C117277713 @default.
- W2075694598 hasConceptScore W2075694598C12554922 @default.
- W2075694598 hasConceptScore W2075694598C129900496 @default.
- W2075694598 hasConceptScore W2075694598C145802702 @default.
- W2075694598 hasConceptScore W2075694598C181199279 @default.
- W2075694598 hasConceptScore W2075694598C185592680 @default.
- W2075694598 hasConceptScore W2075694598C2780161600 @default.
- W2075694598 hasConceptScore W2075694598C2780795997 @default.
- W2075694598 hasConceptScore W2075694598C28406088 @default.
- W2075694598 hasConceptScore W2075694598C43617362 @default.
- W2075694598 hasConceptScore W2075694598C55493867 @default.
- W2075694598 hasConceptScore W2075694598C79879829 @default.
- W2075694598 hasConceptScore W2075694598C86803240 @default.
- W2075694598 hasConceptScore W2075694598C9603476 @default.
- W2075694598 hasLocation W20756945981 @default.
- W2075694598 hasLocation W20756945982 @default.
- W2075694598 hasOpenAccess W2075694598 @default.
- W2075694598 hasPrimaryLocation W20756945981 @default.
- W2075694598 hasRelatedWork W1536377197 @default.
- W2075694598 hasRelatedWork W1548678457 @default.
- W2075694598 hasRelatedWork W1945040619 @default.
- W2075694598 hasRelatedWork W2015730525 @default.
- W2075694598 hasRelatedWork W2075694598 @default.
- W2075694598 hasRelatedWork W2085862980 @default.
- W2075694598 hasRelatedWork W2101559052 @default.
- W2075694598 hasRelatedWork W2136782902 @default.
- W2075694598 hasRelatedWork W2317292539 @default.
- W2075694598 hasRelatedWork W2428568708 @default.
- W2075694598 isParatext "false" @default.
- W2075694598 isRetracted "false" @default.
- W2075694598 magId "2075694598" @default.
- W2075694598 workType "article" @default.