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• W2075694920 startingPage "e7589" @default.
• W2075694920 abstract "Infection of macrophages with the protozoan parasite Toxoplasma gondii results in inhibition of a large panel of LPS-responsive cytokines, including TNF-α, while leaving others such as IL-10 intact. Recent studies provide evidence that the parasite interferes with chromatin remodeling at the TNF-α promoter that is normally associated with LPS stimulation, but that is not required for TLR4 induction of IL-10. Here, we examined the effect of Toxoplasma on IL-10 induced by simultaneous signaling through TLR4 and FcγR, a combined stimulus that triggers histone H3 covalent modification at the IL-10 promoter resulting in high level IL-10 cytokine production. We show that the parasite inhibits high level IL-10 production and prevents histone H3 Ser10 phosphorylation and Lys9/14 acetylation at the IL-10 promoter. These results provide compelling evidence that T. gondii targets the host cell chromatin remodeling machinery to down-regulate cytokine responses in infected macrophages." @default.
• W2075694920 created "2016-06-24" @default.
• W2075694920 creator A5011387477 @default.
• W2075694920 creator A5020919310 @default.
• W2075694920 date "2009-10-27" @default.
• W2075694920 modified "2023-09-27" @default.
• W2075694920 title "Toxoplasma gondii Inhibits Covalent Modification of Histone H3 at the IL-10 Promoter in Infected Macrophages" @default.
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• W2075694920 doi "https://doi.org/10.1371/journal.pone.0007589" @default.
• W2075694920 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2763200" @default.
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