Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075712918> ?p ?o ?g. }
- W2075712918 endingPage "282" @default.
- W2075712918 startingPage "269" @default.
- W2075712918 abstract "Human immunodeficiency virus type 1 (HIV-1) carries a variety of host proteins in addition to virus-encoded structural proteins, both in its envelope and inside the viral particle. Previous studies have reported that the HIV-1 life-cycle is affected by such virus-associated host cell surface proteins. The nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), also known as CD39, is a plasma membrane-bound ectoenzyme that hydrolyzes extracellular ATP and ADP to AMP. It has been shown that CD39 inhibits platelet function, and is thus a critical thromboregulatory molecule. We demonstrate here that host-derived CD39 is acquired by both laboratory-adapted and clinical variants of HIV-1 produced in cellular reservoirs of the virus. Moreover, purified CD39-bearing virions, but not isogenic viruses lacking CD39, display strong ATPase and ADPase activities. It is of particular interest that virions bearing this cellular enzyme can inhibit ADP-induced platelet aggregation, an effect blocked by an NTPDase inhibitor. On the basis of published and the present data on the functionality of human cellular proteins embedded within HIV-1, it can be proposed that these proteins might contribute to some of the immunologic deficiencies seen in infected individuals." @default.
- W2075712918 created "2016-06-24" @default.
- W2075712918 creator A5000780136 @default.
- W2075712918 creator A5012615383 @default.
- W2075712918 creator A5039852039 @default.
- W2075712918 creator A5062570446 @default.
- W2075712918 creator A5071127788 @default.
- W2075712918 date "2007-08-01" @default.
- W2075712918 modified "2023-10-04" @default.
- W2075712918 title "The Nucleoside Triphosphate Diphosphohydrolase-1/CD39 Is Incorporated into Human Immunodeficiency Type 1 Particles, Where It Remains Biologically Active" @default.
- W2075712918 cites W1492226152 @default.
- W2075712918 cites W1498488471 @default.
- W2075712918 cites W1501783126 @default.
- W2075712918 cites W1508924431 @default.
- W2075712918 cites W1519164650 @default.
- W2075712918 cites W1538685980 @default.
- W2075712918 cites W1564075285 @default.
- W2075712918 cites W1565285014 @default.
- W2075712918 cites W1593623110 @default.
- W2075712918 cites W165837497 @default.
- W2075712918 cites W1664638011 @default.
- W2075712918 cites W1792542720 @default.
- W2075712918 cites W1811799314 @default.
- W2075712918 cites W1918855189 @default.
- W2075712918 cites W1965782067 @default.
- W2075712918 cites W1968040201 @default.
- W2075712918 cites W1972546896 @default.
- W2075712918 cites W1977991702 @default.
- W2075712918 cites W1979024995 @default.
- W2075712918 cites W1979339132 @default.
- W2075712918 cites W1982797196 @default.
- W2075712918 cites W1984077320 @default.
- W2075712918 cites W1984595045 @default.
- W2075712918 cites W1987128366 @default.
- W2075712918 cites W1988951550 @default.
- W2075712918 cites W1993334366 @default.
- W2075712918 cites W1994288767 @default.
- W2075712918 cites W2000622245 @default.
- W2075712918 cites W2002451448 @default.
- W2075712918 cites W2003730176 @default.
- W2075712918 cites W2011492906 @default.
- W2075712918 cites W2012355917 @default.
- W2075712918 cites W2014023264 @default.
- W2075712918 cites W2017177951 @default.
- W2075712918 cites W2019783455 @default.
- W2075712918 cites W2020597127 @default.
- W2075712918 cites W2026659052 @default.
- W2075712918 cites W2029100409 @default.
- W2075712918 cites W2032059035 @default.
- W2075712918 cites W2036750318 @default.
- W2075712918 cites W2037948423 @default.
- W2075712918 cites W2043638000 @default.
- W2075712918 cites W2044014719 @default.
- W2075712918 cites W2057442177 @default.
- W2075712918 cites W2064814056 @default.
- W2075712918 cites W2071501185 @default.
- W2075712918 cites W2075865032 @default.
- W2075712918 cites W2084280998 @default.
- W2075712918 cites W2087492008 @default.
- W2075712918 cites W2091696260 @default.
- W2075712918 cites W2092987144 @default.
- W2075712918 cites W2103772763 @default.
- W2075712918 cites W2105115007 @default.
- W2075712918 cites W2105267808 @default.
- W2075712918 cites W2105855967 @default.
- W2075712918 cites W2117134676 @default.
- W2075712918 cites W2117204128 @default.
- W2075712918 cites W2124554623 @default.
- W2075712918 cites W2128364566 @default.
- W2075712918 cites W2145886505 @default.
- W2075712918 cites W2150083988 @default.
- W2075712918 cites W2150656125 @default.
- W2075712918 cites W2151624702 @default.
- W2075712918 cites W2159011164 @default.
- W2075712918 cites W2161003420 @default.
- W2075712918 cites W2162025736 @default.
- W2075712918 cites W2162682093 @default.
- W2075712918 cites W2163146557 @default.
- W2075712918 cites W2163391626 @default.
- W2075712918 cites W2163927795 @default.
- W2075712918 cites W2165280533 @default.
- W2075712918 cites W2168101800 @default.
- W2075712918 cites W2184674306 @default.
- W2075712918 cites W2210954824 @default.
- W2075712918 cites W2253990994 @default.
- W2075712918 cites W2287466453 @default.
- W2075712918 cites W2304439664 @default.
- W2075712918 cites W2394667073 @default.
- W2075712918 cites W2415298862 @default.
- W2075712918 cites W2415990410 @default.
- W2075712918 cites W2462607464 @default.
- W2075712918 cites W2472572692 @default.
- W2075712918 cites W2558440391 @default.
- W2075712918 cites W4229980946 @default.
- W2075712918 cites W4253320561 @default.
- W2075712918 doi "https://doi.org/10.1016/j.jmb.2007.05.012" @default.
- W2075712918 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5239664" @default.
- W2075712918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17560607" @default.