Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075714362> ?p ?o ?g. }
- W2075714362 endingPage "491" @default.
- W2075714362 startingPage "486" @default.
- W2075714362 abstract "IL-6 is a proinflammatory cytokine secreted by tumor cells and immune cells to affect the development of cancer. This study demonstrates the effects of tumor-derived IL-6 on the malignancy of tumor cells and tumor immunity. The tumor cell line, EG7, was transfected with a mammalian expression vector encoding the full length of murine IL-6 to mimic IL-6-secreting tumor cells. Two IL-6 transfectants with low and high IL-6 production were compared in vitro and in vivo. While the in vitro proliferation rates of both transfectants and the parental line were similar, high expression of IL-6 induced a significant reduction in tumor growth in vivo. Concomitantly, there was an increase in IFN-gamma positive tumor-infiltrating lymphocytes and a decrease in the suppressive CD4(+)CD25(+)FoxP3(+) population. These results demonstrate the direct effects of tumor-derived IL-6 on cancer development and the induction of tumor immunity." @default.
- W2075714362 created "2016-06-24" @default.
- W2075714362 creator A5006191599 @default.
- W2075714362 creator A5021020879 @default.
- W2075714362 creator A5025899274 @default.
- W2075714362 creator A5037249264 @default.
- W2075714362 creator A5057240834 @default.
- W2075714362 creator A5069785279 @default.
- W2075714362 creator A5078347051 @default.
- W2075714362 creator A5087571768 @default.
- W2075714362 creator A5088240595 @default.
- W2075714362 creator A5089579478 @default.
- W2075714362 date "2010-06-01" @default.
- W2075714362 modified "2023-10-17" @default.
- W2075714362 title "IL-6-transfected tumor cells modulate the status of CD8+ and CD4+ T cells to control tumor growth" @default.
- W2075714362 cites W1493562779 @default.
- W2075714362 cites W1504397512 @default.
- W2075714362 cites W1530044612 @default.
- W2075714362 cites W1639450499 @default.
- W2075714362 cites W1689083412 @default.
- W2075714362 cites W1777882158 @default.
- W2075714362 cites W1793205621 @default.
- W2075714362 cites W1942750313 @default.
- W2075714362 cites W1966948292 @default.
- W2075714362 cites W1973576115 @default.
- W2075714362 cites W1973965625 @default.
- W2075714362 cites W2001740313 @default.
- W2075714362 cites W2002726823 @default.
- W2075714362 cites W2006704738 @default.
- W2075714362 cites W2021603971 @default.
- W2075714362 cites W2025492877 @default.
- W2075714362 cites W2028194167 @default.
- W2075714362 cites W2032243094 @default.
- W2075714362 cites W2036598270 @default.
- W2075714362 cites W2039754970 @default.
- W2075714362 cites W2042147045 @default.
- W2075714362 cites W2046972425 @default.
- W2075714362 cites W2047536470 @default.
- W2075714362 cites W2061590134 @default.
- W2075714362 cites W2062736692 @default.
- W2075714362 cites W2064621194 @default.
- W2075714362 cites W2076624558 @default.
- W2075714362 cites W2087590639 @default.
- W2075714362 cites W2088420837 @default.
- W2075714362 cites W2097811455 @default.
- W2075714362 cites W2105459360 @default.
- W2075714362 cites W2112792894 @default.
- W2075714362 cites W2113030185 @default.
- W2075714362 cites W2121626779 @default.
- W2075714362 cites W2122656254 @default.
- W2075714362 cites W2127740243 @default.
- W2075714362 cites W2129728624 @default.
- W2075714362 cites W2140160539 @default.
- W2075714362 cites W2144713347 @default.
- W2075714362 cites W2146853858 @default.
- W2075714362 cites W2147350757 @default.
- W2075714362 cites W2147701669 @default.
- W2075714362 cites W2149697600 @default.
- W2075714362 cites W2151098145 @default.
- W2075714362 cites W2151444514 @default.
- W2075714362 cites W2154077842 @default.
- W2075714362 cites W2155779547 @default.
- W2075714362 cites W2157620815 @default.
- W2075714362 cites W2162819001 @default.
- W2075714362 cites W2406137131 @default.
- W2075714362 cites W49894576 @default.
- W2075714362 doi "https://doi.org/10.1016/j.imbio.2009.07.003" @default.
- W2075714362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19699006" @default.
- W2075714362 hasPublicationYear "2010" @default.
- W2075714362 type Work @default.
- W2075714362 sameAs 2075714362 @default.
- W2075714362 citedByCount "8" @default.
- W2075714362 countsByYear W20757143622012 @default.
- W2075714362 countsByYear W20757143622013 @default.
- W2075714362 countsByYear W20757143622015 @default.
- W2075714362 countsByYear W20757143622017 @default.
- W2075714362 countsByYear W20757143622019 @default.
- W2075714362 countsByYear W20757143622021 @default.
- W2075714362 crossrefType "journal-article" @default.
- W2075714362 hasAuthorship W2075714362A5006191599 @default.
- W2075714362 hasAuthorship W2075714362A5021020879 @default.
- W2075714362 hasAuthorship W2075714362A5025899274 @default.
- W2075714362 hasAuthorship W2075714362A5037249264 @default.
- W2075714362 hasAuthorship W2075714362A5057240834 @default.
- W2075714362 hasAuthorship W2075714362A5069785279 @default.
- W2075714362 hasAuthorship W2075714362A5078347051 @default.
- W2075714362 hasAuthorship W2075714362A5087571768 @default.
- W2075714362 hasAuthorship W2075714362A5088240595 @default.
- W2075714362 hasAuthorship W2075714362A5089579478 @default.
- W2075714362 hasConcept C150903083 @default.
- W2075714362 hasConcept C167672396 @default.
- W2075714362 hasConcept C203014093 @default.
- W2075714362 hasConcept C207001950 @default.
- W2075714362 hasConcept C2776090121 @default.
- W2075714362 hasConcept C2778690821 @default.
- W2075714362 hasConcept C2779727006 @default.
- W2075714362 hasConcept C2908647359 @default.
- W2075714362 hasConcept C502942594 @default.