Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075714561> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2075714561 endingPage "205" @default.
- W2075714561 startingPage "197" @default.
- W2075714561 abstract "A simple, specific, accurate and reproducible method for the analysis of isoniazid and its major metabolite, N-acetylisoniazid in urine using high-performance liquid chromatography (HPLC) is described. The assay is performed after extraction of isoniazid, N-acetylisoniazid and 5-(4-methylphenyl)-5-phenylhydantoin (internal standard) from urine using a mixture of chloroform: isopropanol (70:30, v/v) and eluted from a 5 urn C-18 reversed phase column at ambient temperature with a mobile phase consisting of 10 mM sodium acetate: methanol: acetonitrile (40:40:20, v/v) containing 10 mM dioctylsulphosuccinate sodium and adjusted to pH 2·9 with sulphuric acid (< 1 ml), at a flow rate of 1 ml/min with u.v. detection at 266 nm. Quantification was achieved by the measurement of the peak height ratio, and the absolute recoveries ranged from 94 to 99%. Within-day coefficients of variation ranged from 2·81 to 4·54% for isoniazid and from 2·37 to 3·75% for N-acetylisoniazid. Between-day CVs varied from 3·27 to 5·62% and from 2·5 to 4·91% for isoniazid and N-acetylisoniazid, respectively. Preliminary stability tests using a urine sample from a subject showed an increase in mean isoniazid concentration of about 25% after 1 month storage at - 20°C. The method was used for acetylation phenotyping of five individuals." @default.
- W2075714561 created "2016-06-24" @default.
- W2075714561 creator A5056192697 @default.
- W2075714561 creator A5090639415 @default.
- W2075714561 date "1989-06-01" @default.
- W2075714561 modified "2023-10-18" @default.
- W2075714561 title "ACETYLATION PHENOTYPING OF ISONIAZID USING A SIMPLE AND ACCURATE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY" @default.
- W2075714561 cites W138403386 @default.
- W2075714561 cites W1990006342 @default.
- W2075714561 cites W1995959856 @default.
- W2075714561 cites W2041613822 @default.
- W2075714561 cites W2067732089 @default.
- W2075714561 cites W2132294437 @default.
- W2075714561 cites W2146143186 @default.
- W2075714561 cites W2149519060 @default.
- W2075714561 cites W288037188 @default.
- W2075714561 doi "https://doi.org/10.1111/j.1365-2710.1989.tb00238.x" @default.
- W2075714561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2760118" @default.
- W2075714561 hasPublicationYear "1989" @default.
- W2075714561 type Work @default.
- W2075714561 sameAs 2075714561 @default.
- W2075714561 citedByCount "1" @default.
- W2075714561 countsByYear W20757145612014 @default.
- W2075714561 crossrefType "journal-article" @default.
- W2075714561 hasAuthorship W2075714561A5056192697 @default.
- W2075714561 hasAuthorship W2075714561A5090639415 @default.
- W2075714561 hasBestOaLocation W20757145611 @default.
- W2075714561 hasConcept C142724271 @default.
- W2075714561 hasConcept C179998833 @default.
- W2075714561 hasConcept C185592680 @default.
- W2075714561 hasConcept C2776967927 @default.
- W2075714561 hasConcept C2777463227 @default.
- W2075714561 hasConcept C2777477808 @default.
- W2075714561 hasConcept C2780026642 @default.
- W2075714561 hasConcept C2781069245 @default.
- W2075714561 hasConcept C2781144210 @default.
- W2075714561 hasConcept C43617362 @default.
- W2075714561 hasConcept C4725764 @default.
- W2075714561 hasConcept C55493867 @default.
- W2075714561 hasConcept C71924100 @default.
- W2075714561 hasConcept C73826308 @default.
- W2075714561 hasConceptScore W2075714561C142724271 @default.
- W2075714561 hasConceptScore W2075714561C179998833 @default.
- W2075714561 hasConceptScore W2075714561C185592680 @default.
- W2075714561 hasConceptScore W2075714561C2776967927 @default.
- W2075714561 hasConceptScore W2075714561C2777463227 @default.
- W2075714561 hasConceptScore W2075714561C2777477808 @default.
- W2075714561 hasConceptScore W2075714561C2780026642 @default.
- W2075714561 hasConceptScore W2075714561C2781069245 @default.
- W2075714561 hasConceptScore W2075714561C2781144210 @default.
- W2075714561 hasConceptScore W2075714561C43617362 @default.
- W2075714561 hasConceptScore W2075714561C4725764 @default.
- W2075714561 hasConceptScore W2075714561C55493867 @default.
- W2075714561 hasConceptScore W2075714561C71924100 @default.
- W2075714561 hasConceptScore W2075714561C73826308 @default.
- W2075714561 hasIssue "3" @default.
- W2075714561 hasLocation W20757145611 @default.
- W2075714561 hasLocation W20757145612 @default.
- W2075714561 hasOpenAccess W2075714561 @default.
- W2075714561 hasPrimaryLocation W20757145611 @default.
- W2075714561 hasRelatedWork W118183763 @default.
- W2075714561 hasRelatedWork W1825145161 @default.
- W2075714561 hasRelatedWork W1970888742 @default.
- W2075714561 hasRelatedWork W2008727242 @default.
- W2075714561 hasRelatedWork W2035747744 @default.
- W2075714561 hasRelatedWork W2043512602 @default.
- W2075714561 hasRelatedWork W2119552130 @default.
- W2075714561 hasRelatedWork W2150080294 @default.
- W2075714561 hasRelatedWork W2329387523 @default.
- W2075714561 hasRelatedWork W2406364491 @default.
- W2075714561 hasVolume "14" @default.
- W2075714561 isParatext "false" @default.
- W2075714561 isRetracted "false" @default.
- W2075714561 magId "2075714561" @default.
- W2075714561 workType "article" @default.