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- W2075715889 abstract "La (SS-B) is a highly expressed protein that is able to bind 3′-oligouridylate and other common RNA sequence/structural motifs. By virtue of these interactions, La is present in a myriad of nuclear and cytoplasmic ribonucleoprotein complexes in vivo where it may function as an RNA-folding protein or RNA chaperone. We have recently characterized the nuclear import pathway of the S. cerevisiae La, Lhp1p. The soluble transport factor, or karyopherin, that mediates the import of Lhp1p is Kap108p/Sxm1p. We have now determined a 113-amino acid domain of Lhp1p that is brought to the nucleus by Kap108p. Unexpectedly, this domain does not coincide with the previously identified nuclear localization signal of human La. Furthermore, when expressed in Saccharomyces cerevisiae, the nuclear localization of Schizosaccharomyces pombe, Drosophila, and human La proteins are independent of Kap108p. We have been able to reconstitute the nuclear import of human La into permeabilized HeLa cells using the recombinant human factors karyopherin α2, karyopherin β1, Ran, and p10. As such, the yeast and human La proteins are imported using different sequence motifs and dissimilar karyopherins. Our results are consistent with an intermingling of the nuclear import and evolution of La." @default.
- W2075715889 created "2016-06-24" @default.
- W2075715889 creator A5004261586 @default.
- W2075715889 creator A5014175343 @default.
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- W2075715889 date "1998-11-16" @default.
- W2075715889 modified "2023-10-16" @default.
- W2075715889 title "Nuclear Import and the Evolution of a Multifunctional RNA-binding Protein" @default.
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- W2075715889 doi "https://doi.org/10.1083/jcb.143.4.887" @default.
- W2075715889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2132966" @default.
- W2075715889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9817748" @default.
- W2075715889 hasPublicationYear "1998" @default.
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