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- W2075717672 abstract "Abstract The choleretic effect of insulin was studied in anesthetized guinea pigs after ligation of the cystic duct, the pylorus, and cannulation of the common bile duct during intravenous infusion of sodium taurocholate. Insulin caused increased bile flow, increased bicarbonate output, and increased chloride output, but no change in bile salt secretion. Vagotomy and atropine prevented the changes caused by insulin except for an increase in chloride secretion. Canalicular bile formation was estimated by the erythritol clearance method. In experiments in which there was a statistically significant increase in bile flow, insulin had no effect on the biliary clearance of erythritol. The results of these experiments support the hypothesis that insulin choleresis is principally vagally mediated, but there may be a small nonvagal component. Vagal stimulation acts primarily to stimulate secretion from the biliary ductular epithelium and has no measurable effect on canalicular bile production." @default.
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- W2075717672 date "1973-03-01" @default.
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- W2075717672 title "An analysis of the choleretic effect of insulin" @default.
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- W2075717672 doi "https://doi.org/10.1016/0022-4804(73)90131-5" @default.
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