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• W2075719857 abstract "Background: The role of genetic variants in the pathogenesis of stroke has not been fully elucidated. Several studies have been examined the association of the Integrin alpha2 (ITGA2) gene-C807T (rs1126643) polymorphism with ischemic stroke susceptibility. However, the results of these studies are inconsistent. In order to explore this association more deeply, we performed a meta-analysis. Methods: We collected case–control studies concerning the relationship between the C807T polymorphism and ischemic stroke, and odd ratios (OR) with corresponding 95% confidence intervals (CI) were used to describe the relationships. Inconsistency index (I2) and Cochran's Q statistic were used to check heterogeneity. Publication bias was tested by funnel plots and Egger's test. Results: Fifteen studies with 2242 cases and 2408 controls were included. Our meta-analysis results indicated an association between the C807T polymorphism and the risk of ischemic stroke in the overall population, Asians and the subgroup of hospital-based people. However, statistically association was not observed for Caucasians and non-hospitalized individuals. Conclusions: The ITGA2 gene C807T polymorphism may be a susceptible predictor of the risk of ischemic stroke. More data are needed to elucidate the relationship further." @default.
• W2075719857 created "2016-06-24" @default.
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• W2075719857 date "2014-02-13" @default.
• W2075719857 modified "2023-10-03" @default.
• W2075719857 title "Genetic polymorphism of<i>ITGA2</i>C807T can increase the risk of ischemic stroke" @default.
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• W2075719857 doi "https://doi.org/10.3109/00207454.2013.879718" @default.
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