Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075743485> ?p ?o ?g. }
- W2075743485 endingPage "224" @default.
- W2075743485 startingPage "214" @default.
- W2075743485 abstract "In cycling tissues, adult stem cells may be lost and subsequently replaced to ensure homeostasis. To examine the frequency of stem cell replacement, we analyzed the population dynamics of labeled stem cells in steady-state mouse spermatogenesis. Our results show that spermatogenic stem cells are continuously replaced, on average within 2 weeks. The analysis exposes a simple and robust scaling behavior of clone size distributions that shows stem cell replacement to be stochastic, meaning that stem cells are equipotent and equally likely to be lost or to multiply to replace their neighbors, irrespective of their clonal history. The surprisingly fast rate of stem cell replacement is supported experimentally by 3D clone morphology and by live-imaging of spermatogonial migration. These results suggest that short-lived stem cells may be a common feature of mammalian stem cell systems and reveal a natural mechanism for matching the rates of cell proliferation and loss in tissue." @default.
- W2075743485 created "2016-06-24" @default.
- W2075743485 creator A5006854146 @default.
- W2075743485 creator A5015511953 @default.
- W2075743485 creator A5032141728 @default.
- W2075743485 creator A5045449638 @default.
- W2075743485 creator A5064938000 @default.
- W2075743485 date "2010-08-01" @default.
- W2075743485 modified "2023-10-17" @default.
- W2075743485 title "Mouse Germ Line Stem Cells Undergo Rapid and Stochastic Turnover" @default.
- W2075743485 cites W1600103888 @default.
- W2075743485 cites W1972160020 @default.
- W2075743485 cites W1979812265 @default.
- W2075743485 cites W1997919787 @default.
- W2075743485 cites W2002120333 @default.
- W2075743485 cites W2008009288 @default.
- W2075743485 cites W2020411985 @default.
- W2075743485 cites W2026469163 @default.
- W2075743485 cites W2036291312 @default.
- W2075743485 cites W2037048003 @default.
- W2075743485 cites W2042397019 @default.
- W2075743485 cites W2044964424 @default.
- W2075743485 cites W2057641163 @default.
- W2075743485 cites W2063897963 @default.
- W2075743485 cites W2088612857 @default.
- W2075743485 cites W2096530329 @default.
- W2075743485 cites W2098092642 @default.
- W2075743485 cites W2164991328 @default.
- W2075743485 doi "https://doi.org/10.1016/j.stem.2010.05.017" @default.
- W2075743485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20682447" @default.
- W2075743485 hasPublicationYear "2010" @default.
- W2075743485 type Work @default.
- W2075743485 sameAs 2075743485 @default.
- W2075743485 citedByCount "217" @default.
- W2075743485 countsByYear W20757434852012 @default.
- W2075743485 countsByYear W20757434852013 @default.
- W2075743485 countsByYear W20757434852014 @default.
- W2075743485 countsByYear W20757434852015 @default.
- W2075743485 countsByYear W20757434852016 @default.
- W2075743485 countsByYear W20757434852017 @default.
- W2075743485 countsByYear W20757434852018 @default.
- W2075743485 countsByYear W20757434852019 @default.
- W2075743485 countsByYear W20757434852020 @default.
- W2075743485 countsByYear W20757434852021 @default.
- W2075743485 countsByYear W20757434852022 @default.
- W2075743485 countsByYear W20757434852023 @default.
- W2075743485 crossrefType "journal-article" @default.
- W2075743485 hasAuthorship W2075743485A5006854146 @default.
- W2075743485 hasAuthorship W2075743485A5015511953 @default.
- W2075743485 hasAuthorship W2075743485A5032141728 @default.
- W2075743485 hasAuthorship W2075743485A5045449638 @default.
- W2075743485 hasAuthorship W2075743485A5064938000 @default.
- W2075743485 hasBestOaLocation W20757434851 @default.
- W2075743485 hasConcept C104317684 @default.
- W2075743485 hasConcept C109825262 @default.
- W2075743485 hasConcept C14218858 @default.
- W2075743485 hasConcept C144024400 @default.
- W2075743485 hasConcept C148738053 @default.
- W2075743485 hasConcept C149923435 @default.
- W2075743485 hasConcept C201750760 @default.
- W2075743485 hasConcept C2022786 @default.
- W2075743485 hasConcept C20875687 @default.
- W2075743485 hasConcept C28328180 @default.
- W2075743485 hasConcept C2908647359 @default.
- W2075743485 hasConcept C54355233 @default.
- W2075743485 hasConcept C81089528 @default.
- W2075743485 hasConcept C86803240 @default.
- W2075743485 hasConcept C95444343 @default.
- W2075743485 hasConceptScore W2075743485C104317684 @default.
- W2075743485 hasConceptScore W2075743485C109825262 @default.
- W2075743485 hasConceptScore W2075743485C14218858 @default.
- W2075743485 hasConceptScore W2075743485C144024400 @default.
- W2075743485 hasConceptScore W2075743485C148738053 @default.
- W2075743485 hasConceptScore W2075743485C149923435 @default.
- W2075743485 hasConceptScore W2075743485C201750760 @default.
- W2075743485 hasConceptScore W2075743485C2022786 @default.
- W2075743485 hasConceptScore W2075743485C20875687 @default.
- W2075743485 hasConceptScore W2075743485C28328180 @default.
- W2075743485 hasConceptScore W2075743485C2908647359 @default.
- W2075743485 hasConceptScore W2075743485C54355233 @default.
- W2075743485 hasConceptScore W2075743485C81089528 @default.
- W2075743485 hasConceptScore W2075743485C86803240 @default.
- W2075743485 hasConceptScore W2075743485C95444343 @default.
- W2075743485 hasIssue "2" @default.
- W2075743485 hasLocation W20757434851 @default.
- W2075743485 hasLocation W20757434852 @default.
- W2075743485 hasOpenAccess W2075743485 @default.
- W2075743485 hasPrimaryLocation W20757434851 @default.
- W2075743485 hasRelatedWork W1978531099 @default.
- W2075743485 hasRelatedWork W2053342026 @default.
- W2075743485 hasRelatedWork W2071427980 @default.
- W2075743485 hasRelatedWork W2236822702 @default.
- W2075743485 hasRelatedWork W2942732239 @default.
- W2075743485 hasRelatedWork W2959210034 @default.
- W2075743485 hasRelatedWork W2971139100 @default.
- W2075743485 hasRelatedWork W3113980128 @default.
- W2075743485 hasRelatedWork W4312084952 @default.
- W2075743485 hasRelatedWork W4327681888 @default.