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- W2075771613 abstract "Abstract Beagle dogs (four/group) were dosed intramuscularly with netilmicin or tobramycin once daily at doses of 20, 40, or 80 mg/kg. The dogs were dosed for 30 days or until death or sacrifice because of poor condition. Weekly otological examinations (response to Galton whistle) were conducted to evaluate effects on hearing. Hematologic, serum chemical and urinalysis data were collected weekly. Kidneys and cochleas were examined histologically. Dogs given 40 and 80 mg/kg of tobramycin became azotemic and died or were sacrificed in a moribund condition 9 to 22 days after dosing was initiated. Serum urea nitrogen and creatinine levels increased in 2 4 dogs given tobramycin at 20 mg/kg. No clinical signs of toxicity or unusual serum chemical changes occurred in the dogs dosed with netilmicin. Hearing did not appear to be affected by either compound. Microscopic examination of kidneys revealed tubular epithelial necrosis ranging from mild (netilmicin) to severe (tobramycin). Steady-state serum drug concentrations were established at all dose levels for netilmicin. In contrast, serum concentrations of tobramycin increased at all dose levels apparently as a result of nephropathy. Under the conditions of this study, netilmicin was clearly less toxic than tobramycin." @default.
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- W2075771613 date "1980-08-01" @default.
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- W2075771613 title "Comparative toxicity of netilmicin and tobramycin in dogs" @default.
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- W2075771613 doi "https://doi.org/10.1016/0041-008x(80)90233-1" @default.
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