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• W2075782006 abstract "L'étude des mécanismes d'absorption intestinale de l'azote fourni sous forme d'acides aminés, de peptides ou de protéines entières indique que l'azote est absorbé principalement sous forme de di- et tripeptides et d'acides aminés libres. Les systèmes de transport des peptides et des acides aminés libres sont indépendants. Ceux des peptides montrent une capacité supérieure et les maladies membranaires intestinales ne semblent pas avoir d'incidence sur leur fonction. L'existence d'une activité peptidasique dans le plasma suggère la présence de peptides circulants. Les capacités d'absorption intestinale sont diminuées non seulement au cours des pathologies d'origine digestive, mais aussi lors des affections extra-gastroentérologiques ayant un retentissement au niveau du tube digestif. Il s'agit en général des états d'agression, notamment les traumatismes sévères (grands brûlés) qui provoquent un iléus paralytique pendant la phase aiguë, et les états infectieux aigus. Chez les patients en réanimation, l'administration de médicaments produisant des effets secondaires au niveau du tube digestif peut amplifier le syndrome de malabsorption. Dans ces situations cliniques, la diminution des capacités digestives aggrave l'état de dénutrition. The study of the intestinal absorption process of nitrogen provided in the form of amino acids, peptides or whole proteins indicates that nitrogen is absorbed mainly in the form of di- and tripeptides and free amino acids. Peptide and amino acid transport mechanisms are different. Peptide transport systems exhibit a higher capacity, and intestinal membrane diseases do not seem to impair their function. The peptidasic activity noted in the plasma suggests the presence of circulating peptides. Intestinal absorption capacities are impaired not only in diseases originating strictly in the gut, but also in case of other pathologies, which have a secondary impact on gut functions, including a paralytic ileus in the early phase. Pathological states of concern are mostly the situations of stress (e.g. severe burns) and acute infectious episodes. In intensive care unit patients, the use of drugs exhibiting adverse effects on the gut may increase the malabsorption process. In these clinical situations, impairment of digestive capacities worsens the malnutrition state." @default.
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• W2075782006 title "Absorption de l'azote en nutrition entérale. I : bases physiopathologiques" @default.
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