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- W2075782517 abstract "Common fragile sites (CFSs) are regions of the genome with a predisposition to DNA double-strand breaks in response to intrinsic (oncogenic) or extrinsic replication stress. CFS breakage is a common feature in carcinogenesis from its earliest stages. Given that a number of oncogenes and tumor suppressors are located within CFSs, a question that emerges is whether fragility in these regions is only a structural “passive” incident or an event with a profound biological effect. Furthermore, there is sparse evidence that other elements, like non-coding RNAs, are positioned with them. By analyzing data from various libraries, like miRbase and ENCODE, we show a prevalence of various cancer-related genes, miRNAs, and regulatory binding sites, such as CTCF within CFSs. We propose that CFSs are not only susceptible structural domains, but highly organized “functional” entities that when targeted, severe repercussion for cell homeostasis occurs." @default.
- W2075782517 created "2016-06-24" @default.
- W2075782517 creator A5016235730 @default.
- W2075782517 creator A5050170809 @default.
- W2075782517 creator A5051395937 @default.
- W2075782517 creator A5053902049 @default.
- W2075782517 creator A5069835907 @default.
- W2075782517 creator A5082234329 @default.
- W2075782517 date "2014-09-20" @default.
- W2075782517 modified "2023-10-09" @default.
- W2075782517 title "Are common fragile sites merely structural domains or highly organized “functional” units susceptible to oncogenic stress?" @default.
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