Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075793748> ?p ?o ?g. }
- W2075793748 endingPage "e109149" @default.
- W2075793748 startingPage "e109149" @default.
- W2075793748 abstract "Gap junction (GJ) channels have been recognized as an important mechanism for synchronizing neuronal networks. Herein, we investigated the participation of GJ channels in the pilocarpine-induced status epilepticus (SE) by analyzing electrophysiological activity following the blockade of connexins (Cx)-mediated communication. In addition, we examined the regulation of gene expression, protein levels, phosphorylation profile and distribution of neuronal Cx36, Cx45 and glial Cx43 in the rat hippocampus during the acute and latent periods. Electrophysiological recordings revealed that the GJ blockade anticipates the occurrence of low voltage oscillations and promotes a marked reduction of power in all analyzed frequencies.Cx36 gene expression and protein levels remained stable in acute and latent periods, whereas upregulation of Cx45 gene expression and protein redistribution were detected in the latent period. We also observed upregulation of Cx43 mRNA levels followed by changes in the phosphorylation profile and protein accumulation. Taken together, our results indisputably revealed that GJ communication participates in the epileptiform activity induced by pilocarpine. Moreover, considering that specific Cxs undergo alterations through acute and latent periods, this study indicates that the control of GJ communication may represent a focus in reliable anti-epileptogenic strategies." @default.
- W2075793748 created "2016-06-24" @default.
- W2075793748 creator A5017741934 @default.
- W2075793748 creator A5025149347 @default.
- W2075793748 creator A5028934445 @default.
- W2075793748 creator A5031315916 @default.
- W2075793748 creator A5032942816 @default.
- W2075793748 creator A5087290159 @default.
- W2075793748 date "2014-10-09" @default.
- W2075793748 modified "2023-09-26" @default.
- W2075793748 title "Reciprocal Regulation of Epileptiform Neuronal Oscillations and Electrical Synapses in the Rat Hippocampus" @default.
- W2075793748 cites W1493936415 @default.
- W2075793748 cites W1622863588 @default.
- W2075793748 cites W1868109033 @default.
- W2075793748 cites W1924473145 @default.
- W2075793748 cites W1963680371 @default.
- W2075793748 cites W1963848709 @default.
- W2075793748 cites W1967861153 @default.
- W2075793748 cites W1968688696 @default.
- W2075793748 cites W1969183124 @default.
- W2075793748 cites W1971331023 @default.
- W2075793748 cites W1972137417 @default.
- W2075793748 cites W1974420316 @default.
- W2075793748 cites W1978485983 @default.
- W2075793748 cites W1978984610 @default.
- W2075793748 cites W1983710612 @default.
- W2075793748 cites W1988825480 @default.
- W2075793748 cites W1994678566 @default.
- W2075793748 cites W1998432972 @default.
- W2075793748 cites W2000264795 @default.
- W2075793748 cites W2006841348 @default.
- W2075793748 cites W2006958675 @default.
- W2075793748 cites W2008726680 @default.
- W2075793748 cites W2010736218 @default.
- W2075793748 cites W2013258290 @default.
- W2075793748 cites W2013752437 @default.
- W2075793748 cites W2014151097 @default.
- W2075793748 cites W2015510501 @default.
- W2075793748 cites W2016628253 @default.
- W2075793748 cites W2018334671 @default.
- W2075793748 cites W2020608275 @default.
- W2075793748 cites W2024185899 @default.
- W2075793748 cites W2024923637 @default.
- W2075793748 cites W2027856398 @default.
- W2075793748 cites W2030670571 @default.
- W2075793748 cites W2031616221 @default.
- W2075793748 cites W2031630652 @default.
- W2075793748 cites W2034271730 @default.
- W2075793748 cites W2034556040 @default.
- W2075793748 cites W2035784392 @default.
- W2075793748 cites W2039319647 @default.
- W2075793748 cites W2039902359 @default.
- W2075793748 cites W2041715049 @default.
- W2075793748 cites W2044124598 @default.
- W2075793748 cites W2044584270 @default.
- W2075793748 cites W2044679347 @default.
- W2075793748 cites W2045385574 @default.
- W2075793748 cites W2046400378 @default.
- W2075793748 cites W2050659941 @default.
- W2075793748 cites W2057141589 @default.
- W2075793748 cites W2068798732 @default.
- W2075793748 cites W2069305565 @default.
- W2075793748 cites W2074329406 @default.
- W2075793748 cites W2077745510 @default.
- W2075793748 cites W2078214227 @default.
- W2075793748 cites W2078611427 @default.
- W2075793748 cites W2078882437 @default.
- W2075793748 cites W2084723111 @default.
- W2075793748 cites W2086583788 @default.
- W2075793748 cites W2090665192 @default.
- W2075793748 cites W2092046923 @default.
- W2075793748 cites W2094467619 @default.
- W2075793748 cites W2098774830 @default.
- W2075793748 cites W2102561151 @default.
- W2075793748 cites W2105148858 @default.
- W2075793748 cites W2106674032 @default.
- W2075793748 cites W2109091469 @default.
- W2075793748 cites W2111757703 @default.
- W2075793748 cites W2111972881 @default.
- W2075793748 cites W2112140076 @default.
- W2075793748 cites W2114008977 @default.
- W2075793748 cites W2114129147 @default.
- W2075793748 cites W2116048278 @default.
- W2075793748 cites W2116186466 @default.
- W2075793748 cites W2116252215 @default.
- W2075793748 cites W2117947301 @default.
- W2075793748 cites W2124201800 @default.
- W2075793748 cites W2128351400 @default.
- W2075793748 cites W2131056211 @default.
- W2075793748 cites W2131101712 @default.
- W2075793748 cites W2132023891 @default.
- W2075793748 cites W2133025181 @default.
- W2075793748 cites W2138700374 @default.
- W2075793748 cites W2142875089 @default.
- W2075793748 cites W2143203730 @default.
- W2075793748 cites W2145707333 @default.
- W2075793748 cites W2152991135 @default.
- W2075793748 cites W2157586156 @default.