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- W2075802309 abstract "Objective: To evaluate TGF-b and VEGF concentrations in the peritoneal fluid of women with pelvic adhesions and with endometriosis. Design: Descriptive study. Materials/Methods: Patients in a university teaching hospital. Reproductive age women undergoing laparoscopy for pelvic pain or infertility. Aspiration of the peritoneal fluid during laparoscopy. Determination of the concentrations of active TGF-b, latent TGF-b and VEGF in peritoneal fluid. Results: The total (active and latent) TGF-b levels were significantly higher in women with adhesions (201.6 ± 27.6 pM) and endometriosis (196.8 ± 32.5 pM) compared to women without endometriosis and adhesion (control group, 108.0 ± 14.4 pM). Similarly, VEGF levels were significantly higher in women with pelvic adhesions (683.7 ± 81.4 pg/mL) and endometriosis (346.5 ± 124.1 pg/mL) compared to the control group (64.1 ± 8.3 pg/mL). More interestingly, the concentrations of VEGF and biologically active TGF-b in the adhesion group were higher than in the endometriosis group. Conclusions: The concentrations of TGF-b (both bioactive and latent) and VEGF are elevated in the peritoneal fluid of women with pelvic adhesions and with endometriosis. Also, bioactive TGF-b and VEGF levels in the adhesion group are higher than in the endometriosis group. The enhanced expression of VEGF and the increased expression and activation of TGF-b in the peritoneal fluid of women with endometriosis or post-surgical adhesions suggest that these growth factors play a role in the pathogenesis of these conditions. Whether women with elevated peritoneal fluid concentrations of active or latent TGF-b and VEGF are prone to develop adhesions remains to be determined. Supported by: McGill University." @default.
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- W2075802309 date "2001-09-01" @default.
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- W2075802309 title "Elevated vascular endothelial growth factor (VEGF) and active and latent transforming growth factor-β (TGF-β) in the peritoneal fluid of women with pelvic adhesions and with endometriosis." @default.
- W2075802309 doi "https://doi.org/10.1016/s0015-0282(01)02616-4" @default.
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