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• W2075802914 endingPage "3434" @default.
• W2075802914 startingPage "3424" @default.
• W2075802914 abstract "Gene expression in eukaryotes depends upon positioning, mobility and packaging of nucleosomes; thus, we need the detailed information of the human nucleosome core particle (NCP) structure, which could clarify chromatin properties. Here, we report the 2.5 A crystal structure of a human NCP. The overall structure is similar to those of other NCPs reported previously. However, the DNA path of human NCP is remarkably different from that taken within other NCPs with an identical DNA sequence. A comparison of the structural parameters between human and Xenopus laevis DNA reveals that the DNA path of human NCP consecutively shifts by 1 bp in the regions of superhelix axis location -5.0 to -2.0 and 5.0 to 7.0. This alteration of the human DNA path is caused predominantly by tight DNA-DNA contacts within the crystal. It is also likely that the conformational change in the human H2B tail induces the local alteration of the DNA path. In human NCP, the region with the altered DNA path lacks Mn2+ ions and the B-factors of the DNA phosphate groups are substantially high. Therefore, in contrast to the histone octamer, the nucleosomal DNA is sufficiently flexible and mobile and can undergo drastic conformational changes, depending upon the environment." @default.
• W2075802914 created "2016-06-24" @default.
• W2075802914 creator A5074217860 @default.
• W2075802914 date "2005-06-02" @default.
• W2075802914 modified "2023-10-10" @default.
• W2075802914 title "Alteration of the nucleosomal DNA path in the crystal structure of a human nucleosome core particle" @default.
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• W2075802914 doi "https://doi.org/10.1093/nar/gki663" @default.
• W2075802914 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1150222" @default.
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• W2075802914 hasPublicationYear "2005" @default.
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