FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075805613> ?p ?o ?g. }

• W2075805613 abstract "We describe a strategy to introduce preferentially the dominant selectable marker neoR into the human chromosome within a monochromosome hybrid cell line. Integration of a construct containing the marker is mediated by human-specific repeat elements that promote multilocus human-specific integration with a single targeting vector. We tested two classes of repeat elements: the Alu family of SINE repeats and the Line1 repeat family. We show that Alu sequences alone are insufficient to direct human-specific integration but when used in combination with a Line1 element, or when only Line1 elements are included, integration of the vector into the human component of a monochromosome somatic cell hybrid is favored. The vectors also carry sequences that facilitate mapping and selective cloning of the targeted region. This strategy provides a means to generate selectable human subchromosomal fragments that can be used for localization of genes through positional cloning and, more important, for the identification of functional units through DNA transfer." @default.
• W2075805613 created "2016-06-24" @default.
• W2075805613 creator A5007022165 @default.
• W2075805613 creator A5022658762 @default.
• W2075805613 creator A5025803453 @default.
• W2075805613 creator A5042908119 @default.
• W2075805613 creator A5049417438 @default.
• W2075805613 creator A5080528118 @default.
• W2075805613 date "1995-12-01" @default.
• W2075805613 modified "2023-10-16" @default.
• W2075805613 title "Human repeat-mediated integration of selectable markers into somatic cell hybrids." @default.
• W2075805613 cites W1018017158 @default.
• W2075805613 cites W1544560081 @default.
• W2075805613 cites W1800635765 @default.
• W2075805613 cites W1957539018 @default.
• W2075805613 cites W1966189220 @default.
• W2075805613 cites W1968095512 @default.
• W2075805613 cites W1968472660 @default.
• W2075805613 cites W1969399888 @default.
• W2075805613 cites W1969845182 @default.
• W2075805613 cites W1985105823 @default.
• W2075805613 cites W1987610198 @default.
• W2075805613 cites W1989287790 @default.
• W2075805613 cites W1993655388 @default.
• W2075805613 cites W1993834457 @default.
• W2075805613 cites W1997101537 @default.
• W2075805613 cites W1998348841 @default.
• W2075805613 cites W1998364105 @default.
• W2075805613 cites W2003880075 @default.
• W2075805613 cites W2014669590 @default.
• W2075805613 cites W2019113363 @default.
• W2075805613 cites W2019997589 @default.
• W2075805613 cites W2020003480 @default.
• W2075805613 cites W2023470881 @default.
• W2075805613 cites W2024920796 @default.
• W2075805613 cites W2025694793 @default.
• W2075805613 cites W2042171891 @default.
• W2075805613 cites W2047507542 @default.
• W2075805613 cites W2049695709 @default.
• W2075805613 cites W2056840285 @default.
• W2075805613 cites W2060946087 @default.
• W2075805613 cites W2061941091 @default.
• W2075805613 cites W2064535057 @default.
• W2075805613 cites W2066602623 @default.
• W2075805613 cites W2067871613 @default.
• W2075805613 cites W2082178421 @default.
• W2075805613 cites W2082408307 @default.
• W2075805613 cites W2083185301 @default.
• W2075805613 cites W2093223418 @default.
• W2075805613 cites W2113300865 @default.
• W2075805613 cites W2117621343 @default.
• W2075805613 cites W2119400896 @default.
• W2075805613 cites W2121750936 @default.
• W2075805613 cites W2125387792 @default.
• W2075805613 cites W2128098582 @default.
• W2075805613 cites W2128449737 @default.
• W2075805613 cites W2163391143 @default.
• W2075805613 cites W2168263755 @default.
• W2075805613 cites W2323167101 @default.
• W2075805613 cites W2403463782 @default.
• W2075805613 cites W2010088549 @default.
• W2075805613 doi "https://doi.org/10.1101/gr.5.5.444" @default.
• W2075805613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8808465" @default.
• W2075805613 hasPublicationYear "1995" @default.
• W2075805613 type Work @default.
• W2075805613 sameAs 2075805613 @default.
• W2075805613 citedByCount "6" @default.
• W2075805613 countsByYear W20758056132014 @default.
• W2075805613 crossrefType "journal-article" @default.
• W2075805613 hasAuthorship W2075805613A5007022165 @default.
• W2075805613 hasAuthorship W2075805613A5022658762 @default.
• W2075805613 hasAuthorship W2075805613A5025803453 @default.
• W2075805613 hasAuthorship W2075805613A5042908119 @default.
• W2075805613 hasAuthorship W2075805613A5049417438 @default.
• W2075805613 hasAuthorship W2075805613A5080528118 @default.
• W2075805613 hasBestOaLocation W20758056131 @default.
• W2075805613 hasConcept C104317684 @default.
• W2075805613 hasConcept C121050878 @default.
• W2075805613 hasConcept C134305767 @default.
• W2075805613 hasConcept C141231307 @default.
• W2075805613 hasConcept C197077220 @default.
• W2075805613 hasConcept C199360897 @default.
• W2075805613 hasConcept C22744801 @default.
• W2075805613 hasConcept C40767141 @default.
• W2075805613 hasConcept C41008148 @default.
• W2075805613 hasConcept C42411736 @default.
• W2075805613 hasConcept C48931128 @default.
• W2075805613 hasConcept C54355233 @default.
• W2075805613 hasConcept C70721500 @default.
• W2075805613 hasConcept C86803240 @default.
• W2075805613 hasConcept C92087593 @default.
• W2075805613 hasConceptScore W2075805613C104317684 @default.
• W2075805613 hasConceptScore W2075805613C121050878 @default.
• W2075805613 hasConceptScore W2075805613C134305767 @default.
• W2075805613 hasConceptScore W2075805613C141231307 @default.
• W2075805613 hasConceptScore W2075805613C197077220 @default.
• W2075805613 hasConceptScore W2075805613C199360897 @default.
• W2075805613 hasConceptScore W2075805613C22744801 @default.
• W2075805613 hasConceptScore W2075805613C40767141 @default.
• W2075805613 hasConceptScore W2075805613C41008148 @default.

• next