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• W2075831247 endingPage "249" @default.
• W2075831247 startingPage "240" @default.
• W2075831247 abstract "Abstract: To identify potent new antifungal agents, the Candida cell growth inhibitory activities of six lactoferrin (Lf) peptides consisting of 6–25 amino acid residues (peptide 1, FKCRRWQWRMKKLGAPSITCVRRAF = lactoferricin B; peptide 2, FKCRRWQWRM; peptide 2′, FKARRWQWRM; peptide 3, GAPSITCVRRAF; peptide 4, RRWQWR; and peptide 5, RWQWRM) were examined. Of these, peptide 2 strongly suppressed the multiplication of Candida cells, but other peptides showed only weak activities. In two strains of C. albicans, the minimum inhibitory concentration 100 of peptide 2 (17.3 ± 2.2 µ m and 17.5 ± 2.4 µ m ) was close to that of miconazole (13.0 ± 1.7 µ m and 13.1 ± 1.6 µ m ) but markedly different from that of amphotericin B (0.52 ± 0.09 µ m and 0.56 ± 0.11 µ m ). The suppression of Candida cell growth was additively increased by a combination of peptide 2 with amphotericin B and miconazole. Peptides 1, 3, 4 and 5 and Lf suppressed iron uptake by Candida cells, inversely correlated with their Candida cell growth inhibition activities. However, iron uptake was not inhibited by peptide 2. In addition, peptide 2 upregulated Candida cell killing activity of polymorphonuclear leukocytes (PMN) increasing their superoxide generation, protein kinase C activity, p38 MAPK activity and the expression of p47 phox . These results indicated that the main antimicrobial activity of the Lf peptides is dependent on the N‐terminal half of Lf and that the PMN upregulatory activity of peptide 2 and additive function of peptide 2 with antifungal drugs are useful for prophylaxis and control of candidiasis." @default.
• W2075831247 created "2016-06-24" @default.
• W2075831247 creator A5009040647 @default.
• W2075831247 creator A5033568011 @default.
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• W2075831247 date "2001-03-01" @default.
• W2075831247 modified "2023-10-09" @default.
• W2075831247 title "A novel bovine lactoferrin peptide, FKCRRWQWRM, suppresses <i>Candida</i> cell growth and activates neutrophils" @default.
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• W2075831247 cites W1965919360 @default.
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• W2075831247 cites W1973038419 @default.
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• W2075831247 doi "https://doi.org/10.1111/j.1399-3011.2001.00821.x" @default.
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