FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075835114> ?p ?o ?g. }

• W2075835114 endingPage "4257" @default.
• W2075835114 startingPage "4251" @default.
• W2075835114 abstract "The mitochondrial tRNALeu(UUR) (R = A or G) gene possesses several hot spots for pathogenic mutations. A point mutation at nucleotide position 3243 or 3271 is associated with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes and maternally inherited diabetes with deafness. Detailed studies on two tRNAsLeu(UUR) with the 3243 or 3271 mutation revealed some common characteristics in cybrid cells: (i) a decreased life span, resulting in a 70% decrease in the amounts of the tRNAs in the steady state, (ii) a slight decrease in the ratios of aminoacyl-tRNAsLeu(UUR) versusuncharged tRNAsLeu(UUR), and (iii) accurate aminoacylation with leucine without any misacylation. As a marked result, both of the mutant tRNA molecules were deficient in a modification of uridine that occurs in the normal tRNALeu(UUR) at the first position of the anticodon. The lack of this modification may lead to the mistranslation of leucine into non-cognate phenylalanine codons by mutant tRNAsLeu(UUR), according to the mitochondrial wobble rule, and/or a decrease in the rate of mitochondrial protein synthesis. This finding could explain why two different mutations (3243 and 3271) manifest indistinguishable clinical features." @default.
• W2075835114 created "2016-06-24" @default.
• W2075835114 creator A5001653266 @default.
• W2075835114 creator A5044949829 @default.
• W2075835114 creator A5065130731 @default.
• W2075835114 creator A5074541984 @default.
• W2075835114 creator A5083952135 @default.
• W2075835114 date "2000-02-01" @default.
• W2075835114 modified "2023-10-17" @default.
• W2075835114 title "Modification Defect at Anticodon Wobble Nucleotide of Mitochondrial tRNAsLeu(UUR) with Pathogenic Mutations of Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes" @default.
• W2075835114 cites W1515865532 @default.
• W2075835114 cites W1528770098 @default.
• W2075835114 cites W1537491192 @default.
• W2075835114 cites W1969144635 @default.
• W2075835114 cites W1970693337 @default.
• W2075835114 cites W1972237569 @default.
• W2075835114 cites W1976092524 @default.
• W2075835114 cites W1979201731 @default.
• W2075835114 cites W2000111317 @default.
• W2075835114 cites W2005400653 @default.
• W2075835114 cites W2012438556 @default.
• W2075835114 cites W2015422851 @default.
• W2075835114 cites W2017592329 @default.
• W2075835114 cites W2025121505 @default.
• W2075835114 cites W2037204981 @default.
• W2075835114 cites W2037996565 @default.
• W2075835114 cites W2043779724 @default.
• W2075835114 cites W2045409504 @default.
• W2075835114 cites W2065591377 @default.
• W2075835114 cites W2066250257 @default.
• W2075835114 cites W2074934195 @default.
• W2075835114 cites W2076253357 @default.
• W2075835114 cites W2078479092 @default.
• W2075835114 cites W2082798039 @default.
• W2075835114 cites W2083003129 @default.
• W2075835114 cites W2092621425 @default.
• W2075835114 cites W2101395123 @default.
• W2075835114 cites W2104018711 @default.
• W2075835114 cites W2109291482 @default.
• W2075835114 cites W2137675911 @default.
• W2075835114 cites W2138081198 @default.
• W2075835114 cites W2318037856 @default.
• W2075835114 cites W2338125871 @default.
• W2075835114 cites W2516628651 @default.
• W2075835114 cites W408505 @default.
• W2075835114 cites W4234887284 @default.
• W2075835114 cites W954872439 @default.
• W2075835114 cites W1970345057 @default.
• W2075835114 doi "https://doi.org/10.1074/jbc.275.6.4251" @default.
• W2075835114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10660592" @default.
• W2075835114 hasPublicationYear "2000" @default.
• W2075835114 type Work @default.
• W2075835114 sameAs 2075835114 @default.
• W2075835114 citedByCount "238" @default.
• W2075835114 countsByYear W20758351142012 @default.
• W2075835114 countsByYear W20758351142013 @default.
• W2075835114 countsByYear W20758351142014 @default.
• W2075835114 countsByYear W20758351142015 @default.
• W2075835114 countsByYear W20758351142016 @default.
• W2075835114 countsByYear W20758351142017 @default.
• W2075835114 countsByYear W20758351142018 @default.
• W2075835114 countsByYear W20758351142019 @default.
• W2075835114 countsByYear W20758351142020 @default.
• W2075835114 countsByYear W20758351142021 @default.
• W2075835114 countsByYear W20758351142022 @default.
• W2075835114 countsByYear W20758351142023 @default.
• W2075835114 crossrefType "journal-article" @default.
• W2075835114 hasAuthorship W2075835114A5001653266 @default.
• W2075835114 hasAuthorship W2075835114A5044949829 @default.
• W2075835114 hasAuthorship W2075835114A5065130731 @default.
• W2075835114 hasAuthorship W2075835114A5074541984 @default.
• W2075835114 hasAuthorship W2075835114A5083952135 @default.
• W2075835114 hasBestOaLocation W20758351141 @default.
• W2075835114 hasConcept C104317684 @default.
• W2075835114 hasConcept C121332964 @default.
• W2075835114 hasConcept C126322002 @default.
• W2075835114 hasConcept C153957851 @default.
• W2075835114 hasConcept C185592680 @default.
• W2075835114 hasConcept C24586158 @default.
• W2075835114 hasConcept C2775833069 @default.
• W2075835114 hasConcept C2777300911 @default.
• W2075835114 hasConcept C2778621155 @default.
• W2075835114 hasConcept C2780317664 @default.
• W2075835114 hasConcept C501734568 @default.
• W2075835114 hasConcept C50566430 @default.
• W2075835114 hasConcept C54355233 @default.
• W2075835114 hasConcept C55493867 @default.
• W2075835114 hasConcept C67705224 @default.
• W2075835114 hasConcept C71924100 @default.
• W2075835114 hasConcept C74650414 @default.
• W2075835114 hasConcept C86803240 @default.
• W2075835114 hasConceptScore W2075835114C104317684 @default.
• W2075835114 hasConceptScore W2075835114C121332964 @default.
• W2075835114 hasConceptScore W2075835114C126322002 @default.
• W2075835114 hasConceptScore W2075835114C153957851 @default.
• W2075835114 hasConceptScore W2075835114C185592680 @default.
• W2075835114 hasConceptScore W2075835114C24586158 @default.
• W2075835114 hasConceptScore W2075835114C2775833069 @default.

• next