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- W2075845040 abstract "Two recombinant FIPV spike proteins were assessed for their immunogenic properties in 8-week-old kittens, which were then challenged intranasally with FIPV 79-1146. Humoral responses were assessed by ELISA and serum neutralisation test. Changes in PBMC cytokine mRNA levels were detected by a reverse transcription, semiquantitative polymerase chain reaction assay (RT-sqPCR), assessing IL-2, IL-4, IL-6, IL-10, IL-12 and IFNγ. All of the kittens developed clinical signs typical of FIP, which were confirmed on gross post mortem examination. The recombinant proteins induced little or no specific antibody response prior to challenge, and failed to alter the course of disease compared to controls. One week after virus challenge, the stimulated PBMCs showed small increases in the expression of IL-6 and IFNγ mRNA, which correlated with a transient pyrexia. After this time expression of IL-6 mRNA remained unaltered but, as FIP developed, mRNA levels of IL-2, IL-4, IL-10, IL-12 and IFNγ became markedly depressed." @default.
- W2075845040 created "2016-06-24" @default.
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- W2075845040 date "1998-10-01" @default.
- W2075845040 modified "2023-10-16" @default.
- W2075845040 title "Antibody and cytokine responses in kittens during the development of feline infectious peritonitis (FIP)" @default.
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- W2075845040 doi "https://doi.org/10.1016/s0165-2427(98)00156-1" @default.
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