FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075859305> ?p ?o ?g. }

• W2075859305 endingPage "26" @default.
• W2075859305 startingPage "15" @default.
• W2075859305 abstract "A chitosan derivative as an acetate salt was successfully prepared by using a spray drying technique. Physicochemical characteristics and micromeritic properties of spray-dried chitosan acetate (SD-CSA) were studied as well as drug-polymer and excipient-polymer interaction. SD-CSA was spherical agglomerates with rough surface and less than 75 microm in diameter. The salt was an amorphous solid with slight to moderate hygroscopicity. The results of Fourier transform infrared (FTIR) and solid-state (13)C NMR spectroscopy demonstrated the functional groups of an acetate salt in its molecular structure. DSC and TGA thermograms of SD-CSA as well as FTIR and NMR spectrum of the salt, heated at 120 degrees C for 12 h, revealed the evidence of the conversion of chitosan acetate molecular structure to N-acetylglucosamine at higher temperature. No interaction of SD-CSA with either drugs (salicylic acid and theophylline) or selected pharmaceutical excipients were observed in the study using DSC method. As a wet granulation binder, SD-CSA gave theophylline granules with good flowability (according to the value of angle of repose, Carr's index, and Hausner ratio) and an excellent compressibility profile comparable to a pharmaceutical binder, PVP K30. In vitro release study of theophylline from the tablets containing 3% w/w SD-CSA as a binder demonstrated sustained drug release in all media. Cumulative drug released in 0.1 N HCl, pH 6.8 phosphate buffer and distilled water was nearly 100% within 6, 16 and 24 h, respectively. It was suggested that the simple incorporation of spray-dried chitosan acetate as a tablet binder could give rise to controlled drug delivery systems exhibiting sustained drug release." @default.
• W2075859305 created "2016-06-24" @default.
• W2075859305 creator A5012438595 @default.
• W2075859305 creator A5019752861 @default.
• W2075859305 creator A5020733380 @default.
• W2075859305 creator A5034782388 @default.
• W2075859305 creator A5055009861 @default.
• W2075859305 creator A5055255188 @default.
• W2075859305 creator A5063366713 @default.
• W2075859305 date "2004-09-01" @default.
• W2075859305 modified "2023-10-18" @default.
• W2075859305 title "Characterization of chitosan acetate as a binder for sustained release tablets" @default.
• W2075859305 cites W108982010 @default.
• W2075859305 cites W1485145206 @default.
• W2075859305 cites W1562907393 @default.
• W2075859305 cites W1973214889 @default.
• W2075859305 cites W1980296334 @default.
• W2075859305 cites W1980453949 @default.
• W2075859305 cites W1983073000 @default.
• W2075859305 cites W1983473009 @default.
• W2075859305 cites W1986642538 @default.
• W2075859305 cites W1989599554 @default.
• W2075859305 cites W1991928548 @default.
• W2075859305 cites W1997080421 @default.
• W2075859305 cites W2001788033 @default.
• W2075859305 cites W2002157883 @default.
• W2075859305 cites W2002892970 @default.
• W2075859305 cites W2005610781 @default.
• W2075859305 cites W2006548788 @default.
• W2075859305 cites W2020965530 @default.
• W2075859305 cites W2024089460 @default.
• W2075859305 cites W2035554303 @default.
• W2075859305 cites W2043502318 @default.
• W2075859305 cites W2051761858 @default.
• W2075859305 cites W2072323564 @default.
• W2075859305 cites W2072325032 @default.
• W2075859305 cites W2088146157 @default.
• W2075859305 cites W2090296204 @default.
• W2075859305 cites W2101504304 @default.
• W2075859305 cites W2134248771 @default.
• W2075859305 cites W2152236375 @default.
• W2075859305 cites W2333196314 @default.
• W2075859305 doi "https://doi.org/10.1016/j.jconrel.2004.06.008" @default.
• W2075859305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15342177" @default.
• W2075859305 hasPublicationYear "2004" @default.
• W2075859305 type Work @default.
• W2075859305 sameAs 2075859305 @default.
• W2075859305 citedByCount "141" @default.
• W2075859305 countsByYear W20758593052012 @default.
• W2075859305 countsByYear W20758593052013 @default.
• W2075859305 countsByYear W20758593052014 @default.
• W2075859305 countsByYear W20758593052015 @default.
• W2075859305 countsByYear W20758593052016 @default.
• W2075859305 countsByYear W20758593052017 @default.
• W2075859305 countsByYear W20758593052018 @default.
• W2075859305 countsByYear W20758593052019 @default.
• W2075859305 countsByYear W20758593052020 @default.
• W2075859305 countsByYear W20758593052021 @default.
• W2075859305 countsByYear W20758593052022 @default.
• W2075859305 countsByYear W20758593052023 @default.
• W2075859305 crossrefType "journal-article" @default.
• W2075859305 hasAuthorship W2075859305A5012438595 @default.
• W2075859305 hasAuthorship W2075859305A5019752861 @default.
• W2075859305 hasAuthorship W2075859305A5020733380 @default.
• W2075859305 hasAuthorship W2075859305A5034782388 @default.
• W2075859305 hasAuthorship W2075859305A5055009861 @default.
• W2075859305 hasAuthorship W2075859305A5055255188 @default.
• W2075859305 hasAuthorship W2075859305A5063366713 @default.
• W2075859305 hasConcept C127413603 @default.
• W2075859305 hasConcept C134018914 @default.
• W2075859305 hasConcept C13965031 @default.
• W2075859305 hasConcept C159985019 @default.
• W2075859305 hasConcept C160892712 @default.
• W2075859305 hasConcept C178790620 @default.
• W2075859305 hasConcept C185592680 @default.
• W2075859305 hasConcept C192562407 @default.
• W2075859305 hasConcept C2777239854 @default.
• W2075859305 hasConcept C2778095195 @default.
• W2075859305 hasConcept C2779429693 @default.
• W2075859305 hasConcept C2779732960 @default.
• W2075859305 hasConcept C42360764 @default.
• W2075859305 hasConcept C43617362 @default.
• W2075859305 hasConcept C71924100 @default.
• W2075859305 hasConcept C88463166 @default.
• W2075859305 hasConceptScore W2075859305C127413603 @default.
• W2075859305 hasConceptScore W2075859305C134018914 @default.
• W2075859305 hasConceptScore W2075859305C13965031 @default.
• W2075859305 hasConceptScore W2075859305C159985019 @default.
• W2075859305 hasConceptScore W2075859305C160892712 @default.
• W2075859305 hasConceptScore W2075859305C178790620 @default.
• W2075859305 hasConceptScore W2075859305C185592680 @default.
• W2075859305 hasConceptScore W2075859305C192562407 @default.
• W2075859305 hasConceptScore W2075859305C2777239854 @default.
• W2075859305 hasConceptScore W2075859305C2778095195 @default.
• W2075859305 hasConceptScore W2075859305C2779429693 @default.
• W2075859305 hasConceptScore W2075859305C2779732960 @default.
• W2075859305 hasConceptScore W2075859305C42360764 @default.
• W2075859305 hasConceptScore W2075859305C43617362 @default.

• next