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- W2075890761 abstract "Over the past decade the possibility of membrane abnormalities in hypertension has been studied very extensively. These studies reflect the putative significance of membrane abnormalities in the pathogenesis of this disease, and the need for resolution of the great divergence of the results that have been reported. Nevertheless, two sound generalizations have emerged from studies of the plasma membrane in hypertension: 1) The microviscosity of the plasma membrane is elevated (fluidity is decreased). However, genetic studies have cast doubt on the possibility that the decreased fluidity of the plasma membrane plays a role in the cause of experimental hypertension. 2) The stabilizing influence of calcium is diminished. The roles, if any, of these two abnormalities in the pathogenesis of hypertension require further study. Specific abnormalities, such as that of the Na/Li countertransport or Na/H exchange activity, may be useful phenotypic markers of subgroups of patients with essential hypertension. (Hypertens Res 1994; 17: 79-86)" @default.
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- W2075890761 date "1994-01-01" @default.
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- W2075890761 title "Plasma Membrane in Hypertension: Microviscosity and Calcium Stabilization." @default.
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- W2075890761 doi "https://doi.org/10.1291/hypres.17.79" @default.
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