FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075907691> ?p ?o ?g. }

• W2075907691 endingPage "127" @default.
• W2075907691 startingPage "115" @default.
• W2075907691 abstract "Three hallmark features of the cardiac hypertrophic growth program are increases in cell size, sarcomeric organization, and the induction of certain cardiac-specific genes. All three features of hypertrophy are induced in cultured myocardial cells by α1- adrenergic receptor agonists, such as phenylephrine (PE) and other growth factors that activate mitogen- activated protein kinases (MAPKs). In this study the MAPK family members extracellular signal–regulated kinase (ERK), c-jun NH2-terminal kinase (JNK), and p38 were activated by transfecting cultured cardiac myocytes with constructs encoding the appropriate kinases possessing gain-of-function mutations. Transfected cells were then analyzed for changes in cell size, sarcomeric organization, and induction of the genes for the A- and B-type natriuretic peptides (NPs), as well as the α-skeletal actin (α-SkA) gene. While activation of JNK and/or ERK with MEKK1COOH or Raf-1 BXB, respectively, augmented cell size and effected relatively modest increases in NP and α-SkA promoter activities, neither upstream kinase conferred sarcomeric organization. However, transfection with MKK6 (Glu), which specifically activated p38, augmented cell size, induced NP and α-Ska promoter activities by up to 130-fold, and elicited sarcomeric organization in a manner similar to PE. Moreover, all three growth features induced by MKK6 (Glu) or PE were blocked with the p38-specific inhibitor, SB 203580. These results demonstrate novel and potentially central roles for MKK6 and p38 in the regulation of myocardial cell hypertrophy." @default.
• W2075907691 created "2016-06-24" @default.
• W2075907691 creator A5000005485 @default.
• W2075907691 creator A5002631983 @default.
• W2075907691 creator A5024429848 @default.
• W2075907691 creator A5048050187 @default.
• W2075907691 creator A5082493706 @default.
• W2075907691 date "1997-10-06" @default.
• W2075907691 modified "2023-10-14" @default.
• W2075907691 title "A Role for the p38 Mitogen-activated Protein Kinase Pathway in Myocardial Cell Growth, Sarcomeric Organization, and Cardiac-specific Gene Expression" @default.
• W2075907691 cites W10260794 @default.
• W2075907691 cites W1482605042 @default.
• W2075907691 cites W1489316903 @default.
• W2075907691 cites W1493738841 @default.
• W2075907691 cites W1504962329 @default.
• W2075907691 cites W1505825810 @default.
• W2075907691 cites W1526362532 @default.
• W2075907691 cites W1526435453 @default.
• W2075907691 cites W1531450317 @default.
• W2075907691 cites W1540426161 @default.
• W2075907691 cites W1560653098 @default.
• W2075907691 cites W1565234800 @default.
• W2075907691 cites W1566502635 @default.
• W2075907691 cites W1573821584 @default.
• W2075907691 cites W1597602621 @default.
• W2075907691 cites W1742295292 @default.
• W2075907691 cites W1749711544 @default.
• W2075907691 cites W1810029706 @default.
• W2075907691 cites W1813567193 @default.
• W2075907691 cites W1900272118 @default.
• W2075907691 cites W1968672667 @default.
• W2075907691 cites W1969785844 @default.
• W2075907691 cites W1970265839 @default.
• W2075907691 cites W1970749013 @default.
• W2075907691 cites W1971334343 @default.
• W2075907691 cites W1976385326 @default.
• W2075907691 cites W1976462601 @default.
• W2075907691 cites W1978221784 @default.
• W2075907691 cites W1983207595 @default.
• W2075907691 cites W1984665850 @default.
• W2075907691 cites W1984903682 @default.
• W2075907691 cites W1987339712 @default.
• W2075907691 cites W1994866601 @default.
• W2075907691 cites W1998487776 @default.
• W2075907691 cites W2005900169 @default.
• W2075907691 cites W2007501972 @default.
• W2075907691 cites W2007986629 @default.
• W2075907691 cites W2008343355 @default.
• W2075907691 cites W2020533186 @default.
• W2075907691 cites W2021858086 @default.
• W2075907691 cites W2022914311 @default.
• W2075907691 cites W2025548430 @default.
• W2075907691 cites W2025694469 @default.
• W2075907691 cites W2030900078 @default.
• W2075907691 cites W2036985660 @default.
• W2075907691 cites W2037241011 @default.
• W2075907691 cites W2038170564 @default.
• W2075907691 cites W2050162178 @default.
• W2075907691 cites W2051538397 @default.
• W2075907691 cites W2052058015 @default.
• W2075907691 cites W2053347615 @default.
• W2075907691 cites W2057126981 @default.
• W2075907691 cites W2062255318 @default.
• W2075907691 cites W2062892401 @default.
• W2075907691 cites W2062919057 @default.
• W2075907691 cites W2072061824 @default.
• W2075907691 cites W2073541193 @default.
• W2075907691 cites W2080999736 @default.
• W2075907691 cites W2086525709 @default.
• W2075907691 cites W2093125387 @default.
• W2075907691 cites W2094179447 @default.
• W2075907691 cites W2094465056 @default.
• W2075907691 cites W2106105420 @default.
• W2075907691 cites W2110889457 @default.
• W2075907691 cites W2112431248 @default.
• W2075907691 cites W2118897660 @default.
• W2075907691 cites W2125426078 @default.
• W2075907691 cites W2133181350 @default.
• W2075907691 cites W2141108927 @default.
• W2075907691 cites W2145086834 @default.
• W2075907691 cites W2146217294 @default.
• W2075907691 cites W2147678437 @default.
• W2075907691 cites W2158455388 @default.
• W2075907691 cites W2160013321 @default.
• W2075907691 cites W2162333016 @default.
• W2075907691 cites W2164340078 @default.
• W2075907691 cites W2166527628 @default.
• W2075907691 cites W2169103231 @default.
• W2075907691 cites W2171569176 @default.
• W2075907691 cites W2181679132 @default.
• W2075907691 cites W2397900205 @default.
• W2075907691 doi "https://doi.org/10.1083/jcb.139.1.115" @default.
• W2075907691 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2139826" @default.
• W2075907691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9314533" @default.
• W2075907691 hasPublicationYear "1997" @default.
• W2075907691 type Work @default.
• W2075907691 sameAs 2075907691 @default.
• W2075907691 citedByCount "306" @default.

• next