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- W2075920491 abstract "Ovine submaxillary gland mucoprotein (OSM), the most potent of the influenza virus haemagglutinin inhibitors, was found to contain equimolecular amounts of N-acetylneuraminic acid and N-acetylgalactosamine comprising 42% of the mucoprotein. The prosthetic group was isolated and shown to be the disaccharide 6-α-D-N-acetylneuraminyl-N-acetylgalactosamine by elementary analysis, identification of its components, susceptibility to α-neuraminidase and periodate consumption. The derivative 6-α-D-N-acetylneuraminyl-anhydro-N-acetyl-galactosamine, a chromogen in the direct Ehlrich reaction in the cold, formed from the prosthetic group on gentle alkali treatment, was also prepared. 93% of the total galactosamine of OSM was oxidized by periodate, and 85% of the N-acetylneuraminic acid was released by α-neuraminidase concomitant with the loss of biological activity." @default.
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- W2075920491 date "1960-01-01" @default.
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- W2075920491 title "Studies of mucoproteins I. The structure of the prosthetic group of ovine submaxillary gland mucoprotein" @default.
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- W2075920491 doi "https://doi.org/10.1016/0006-3002(60)91286-5" @default.
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