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• W2075935596 abstract "Hormesis, a stress tolerance, can be induced by ischemic preconditioning stress. In addition to preconditioning, it may be induced by other means, such as gas anesthetics. Preconditioning mechanisms, which may be mediated by reprogramming survival genes and proteins, are obscure. A known neurotoxicant, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), causes less neurotoxicity in the mice that are preconditioned. Pharmacological evidences suggest that the signaling pathway of NO–cGMP–PKG (protein kinase G) may mediate preconditioning phenomenon. We developed a human SH-SY5Y cell model for investigating NO-mediated signaling pathway, gene regulation, and protein expression following a sublethal preconditioning stress caused by a brief 2-h serum deprivation. Preconditioned human SH-SY5Y cells are more resistant against severe oxidative stress and apoptosis caused by lethal serum deprivation and 1-mehtyl-4-phenylpyridinium (MPP+). Both sublethal and lethal oxidative stress caused by serum withdrawal increased neuronal nitric oxide synthase (nNOS/NOS1) expression and NO levels to a similar extent. In addition to free radical scavengers, inhibition of nNOS, guanylyl cyclase, and PKG blocks hormesis induced by preconditioning. S-nitrosothiols and 6-Br-cGMP produce a cytoprotection mimicking the action of preconditioning tolerance. There are two distinct cGMP-mediated survival pathways: (i) the up-regulation of a redox protein thioredoxin (Trx) for elevating mitochondrial levels of antioxidant protein Mn superoxide dismutase (MnSOD) and antiapoptotic protein Bcl-2, and (ii) the activation of mitochondrial ATP-sensitive potassium channels [K(ATP)]. Preconditioning induction of Trx increased tolerance against MPP+, which was blocked by Trx mRNA antisense oligonucleotide and Trx reductase inhibitor. It is concluded that Trx plays a pivotal role in NO-dependent preconditioning hormesis against MPTP/MPP+." @default.
• W2075935596 created "2016-06-24" @default.
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• W2075935596 date "2005-09-01" @default.
• W2075935596 modified "2023-09-24" @default.
• W2075935596 title "Roles of thioredoxin in nitric oxide-dependent preconditioning-induced tolerance against MPTP neurotoxin" @default.
• W2075935596 cites W1487926242 @default.
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• W2075935596 cites W1601393008 @default.
• W2075935596 cites W1766190906 @default.
• W2075935596 cites W1838828609 @default.
• W2075935596 cites W1965807969 @default.
• W2075935596 cites W1966514812 @default.
• W2075935596 cites W1968091674 @default.
• W2075935596 cites W1968269211 @default.
• W2075935596 cites W1969001174 @default.
• W2075935596 cites W1969268163 @default.
• W2075935596 cites W1970498090 @default.
• W2075935596 cites W1975597097 @default.
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• W2075935596 cites W1980680117 @default.
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• W2075935596 cites W2000462205 @default.
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• W2075935596 cites W2013040616 @default.
• W2075935596 cites W2013371338 @default.
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• W2075935596 cites W2026879988 @default.
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• W2075935596 doi "https://doi.org/10.1016/j.taap.2005.03.020" @default.
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