Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075939968> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2075939968 endingPage "1187" @default.
- W2075939968 startingPage "1183" @default.
- W2075939968 abstract "An osteotropic drug delivery system (ODDS) based on a bisphosphonic prodrug has been developed for 17β-estradiol (E2) to improve patient compliance in estrogen replacement therapy of postmenopausal osteoporosis. The biological disposition and the targeting efficiency of a bisphosphonic prodrug of E2, disodium [17β-(3'-hydroxy-1', 3', 5'-estratrienyloxy)carbonylpropyl carboxamidomethylene]bisphosphonate (E2-BP), was investigated in ovariectomized rats. After intravenous injection, E2-BP was rapidly taken up into the bone and subsequently cleared from the bone at a half-life of 13.5d. The bone concentration of regenerated E2 was maintained throughout 28d. In contrast, E2 injected intravenously showed extremely low bone distribution and rapid clearance from the bone, and E2 administered orally showed even lower bone distribution. Therapeutic availability (TA) and drug targeting index (DTI), which were calculated on the basis of the AUCs for E2 in the bone and plasma after injection of E2-BP and E2, were 64.6 and 451, respectively. These results suggest that ODDS has a potential to improve not only the apparent potency but also the therapeutic index of E2. As compared with the conventional estrogenic products, E2-BP should improve patient compliance with lower adverse effects and less frequent medication in long-term estrogen replacement therapy." @default.
- W2075939968 created "2016-06-24" @default.
- W2075939968 creator A5011399902 @default.
- W2075939968 creator A5016839836 @default.
- W2075939968 creator A5017776579 @default.
- W2075939968 creator A5029799259 @default.
- W2075939968 creator A5031099621 @default.
- W2075939968 creator A5070170970 @default.
- W2075939968 date "1997-01-01" @default.
- W2075939968 modified "2023-10-03" @default.
- W2075939968 title "Osteotropic Drug Delivery System (ODDS) Based on Bisphosphonic Prodrug. V. Biological Disposition and Targeting Characteristics of Osteotropic Estradiol." @default.
- W2075939968 cites W2002327991 @default.
- W2075939968 doi "https://doi.org/10.1248/bpb.20.1183" @default.
- W2075939968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9401729" @default.
- W2075939968 hasPublicationYear "1997" @default.
- W2075939968 type Work @default.
- W2075939968 sameAs 2075939968 @default.
- W2075939968 citedByCount "25" @default.
- W2075939968 countsByYear W20759399682012 @default.
- W2075939968 countsByYear W20759399682014 @default.
- W2075939968 countsByYear W20759399682016 @default.
- W2075939968 countsByYear W20759399682017 @default.
- W2075939968 countsByYear W20759399682020 @default.
- W2075939968 countsByYear W20759399682023 @default.
- W2075939968 crossrefType "journal-article" @default.
- W2075939968 hasAuthorship W2075939968A5011399902 @default.
- W2075939968 hasAuthorship W2075939968A5016839836 @default.
- W2075939968 hasAuthorship W2075939968A5017776579 @default.
- W2075939968 hasAuthorship W2075939968A5029799259 @default.
- W2075939968 hasAuthorship W2075939968A5031099621 @default.
- W2075939968 hasAuthorship W2075939968A5070170970 @default.
- W2075939968 hasBestOaLocation W20759399681 @default.
- W2075939968 hasConcept C108215921 @default.
- W2075939968 hasConcept C110121322 @default.
- W2075939968 hasConcept C112705442 @default.
- W2075939968 hasConcept C126322002 @default.
- W2075939968 hasConcept C134306372 @default.
- W2075939968 hasConcept C170033053 @default.
- W2075939968 hasConcept C178790620 @default.
- W2075939968 hasConcept C185592680 @default.
- W2075939968 hasConcept C19831878 @default.
- W2075939968 hasConcept C2776169692 @default.
- W2075939968 hasConcept C2776541429 @default.
- W2075939968 hasConcept C2777164284 @default.
- W2075939968 hasConcept C2777251235 @default.
- W2075939968 hasConcept C2779820397 @default.
- W2075939968 hasConcept C2780035454 @default.
- W2075939968 hasConcept C33923547 @default.
- W2075939968 hasConcept C71924100 @default.
- W2075939968 hasConcept C8264082 @default.
- W2075939968 hasConcept C98274493 @default.
- W2075939968 hasConceptScore W2075939968C108215921 @default.
- W2075939968 hasConceptScore W2075939968C110121322 @default.
- W2075939968 hasConceptScore W2075939968C112705442 @default.
- W2075939968 hasConceptScore W2075939968C126322002 @default.
- W2075939968 hasConceptScore W2075939968C134306372 @default.
- W2075939968 hasConceptScore W2075939968C170033053 @default.
- W2075939968 hasConceptScore W2075939968C178790620 @default.
- W2075939968 hasConceptScore W2075939968C185592680 @default.
- W2075939968 hasConceptScore W2075939968C19831878 @default.
- W2075939968 hasConceptScore W2075939968C2776169692 @default.
- W2075939968 hasConceptScore W2075939968C2776541429 @default.
- W2075939968 hasConceptScore W2075939968C2777164284 @default.
- W2075939968 hasConceptScore W2075939968C2777251235 @default.
- W2075939968 hasConceptScore W2075939968C2779820397 @default.
- W2075939968 hasConceptScore W2075939968C2780035454 @default.
- W2075939968 hasConceptScore W2075939968C33923547 @default.
- W2075939968 hasConceptScore W2075939968C71924100 @default.
- W2075939968 hasConceptScore W2075939968C8264082 @default.
- W2075939968 hasConceptScore W2075939968C98274493 @default.
- W2075939968 hasIssue "11" @default.
- W2075939968 hasLocation W20759399681 @default.
- W2075939968 hasLocation W20759399682 @default.
- W2075939968 hasOpenAccess W2075939968 @default.
- W2075939968 hasPrimaryLocation W20759399681 @default.
- W2075939968 hasRelatedWork W1906640546 @default.
- W2075939968 hasRelatedWork W1973947102 @default.
- W2075939968 hasRelatedWork W2063620044 @default.
- W2075939968 hasRelatedWork W2075939968 @default.
- W2075939968 hasRelatedWork W2108578925 @default.
- W2075939968 hasRelatedWork W2117873459 @default.
- W2075939968 hasRelatedWork W2144210769 @default.
- W2075939968 hasRelatedWork W2276706948 @default.
- W2075939968 hasRelatedWork W2731568393 @default.
- W2075939968 hasRelatedWork W3204548441 @default.
- W2075939968 hasVolume "20" @default.
- W2075939968 isParatext "false" @default.
- W2075939968 isRetracted "false" @default.
- W2075939968 magId "2075939968" @default.
- W2075939968 workType "article" @default.