FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075951102> ?p ?o ?g. }

• W2075951102 endingPage "e1000213" @default.
• W2075951102 startingPage "e1000213" @default.
• W2075951102 abstract "Biogenesis of ribosomes is an essential cellular process conserved across all eukaryotes and is known to require >170 genes for the assembly, modification, and trafficking of ribosome components through multiple cellular compartments. Despite intensive study, this pathway likely involves many additional genes. Here, we employ network-guided genetics—an approach for associating candidate genes with biological processes that capitalizes on recent advances in functional genomic and proteomic studies—to computationally identify additional ribosomal biogenesis genes. We experimentally evaluated >100 candidate yeast genes in a battery of assays, confirming involvement of at least 15 new genes, including previously uncharacterized genes (YDL063C, YIL091C, YOR287C, YOR006C/TSR3, YOL022C/TSR4). We associate the new genes with specific aspects of ribosomal subunit maturation, ribosomal particle association, and ribosomal subunit nuclear export, and we identify genes specifically required for the processing of 5S, 7S, 20S, 27S, and 35S rRNAs. These results reveal new connections between ribosome biogenesis and mRNA splicing and add >10% new genes—most with human orthologs—to the biogenesis pathway, significantly extending our understanding of a universally conserved eukaryotic process." @default.
• W2075951102 created "2016-06-24" @default.
• W2075951102 creator A5001720031 @default.
• W2075951102 creator A5009324727 @default.
• W2075951102 creator A5035867403 @default.
• W2075951102 creator A5048213452 @default.
• W2075951102 creator A5059129180 @default.
• W2075951102 creator A5079751395 @default.
• W2075951102 date "2009-10-06" @default.
• W2075951102 modified "2023-09-23" @default.
• W2075951102 title "Rational Extension of the Ribosome Biogenesis Pathway Using Network-Guided Genetics" @default.
• W2075951102 cites W1533936090 @default.
• W2075951102 cites W1549520851 @default.
• W2075951102 cites W1554349566 @default.
• W2075951102 cites W1582510605 @default.
• W2075951102 cites W1597678601 @default.
• W2075951102 cites W1964249992 @default.
• W2075951102 cites W1967821301 @default.
• W2075951102 cites W1968453920 @default.
• W2075951102 cites W1974220691 @default.
• W2075951102 cites W1975749924 @default.
• W2075951102 cites W1975972022 @default.
• W2075951102 cites W1976386441 @default.
• W2075951102 cites W1976732266 @default.
• W2075951102 cites W1977979969 @default.
• W2075951102 cites W1979566118 @default.
• W2075951102 cites W1988309554 @default.
• W2075951102 cites W1990214042 @default.
• W2075951102 cites W1997504014 @default.
• W2075951102 cites W2010325815 @default.
• W2075951102 cites W2012987716 @default.
• W2075951102 cites W2013303176 @default.
• W2075951102 cites W2013947447 @default.
• W2075951102 cites W2015556811 @default.
• W2075951102 cites W2025905237 @default.
• W2075951102 cites W2028121863 @default.
• W2075951102 cites W2036314702 @default.
• W2075951102 cites W2037973887 @default.
• W2075951102 cites W2039461665 @default.
• W2075951102 cites W2039531009 @default.
• W2075951102 cites W2040581784 @default.
• W2075951102 cites W2041703851 @default.
• W2075951102 cites W2046108408 @default.
• W2075951102 cites W2047024375 @default.
• W2075951102 cites W2048604500 @default.
• W2075951102 cites W2050721857 @default.
• W2075951102 cites W2054315165 @default.
• W2075951102 cites W2058904982 @default.
• W2075951102 cites W2062009669 @default.
• W2075951102 cites W2071041831 @default.
• W2075951102 cites W2074026981 @default.
• W2075951102 cites W2074405508 @default.
• W2075951102 cites W2074755764 @default.
• W2075951102 cites W2081133503 @default.
• W2075951102 cites W2086638152 @default.
• W2075951102 cites W2086779374 @default.
• W2075951102 cites W2087926131 @default.
• W2075951102 cites W2089667459 @default.
• W2075951102 cites W2094874234 @default.
• W2075951102 cites W2096096354 @default.
• W2075951102 cites W2097773718 @default.
• W2075951102 cites W2098370509 @default.
• W2075951102 cites W2098646876 @default.
• W2075951102 cites W2099308993 @default.
• W2075951102 cites W2109327803 @default.
• W2075951102 cites W2116360991 @default.
• W2075951102 cites W2120858595 @default.
• W2075951102 cites W2120959840 @default.
• W2075951102 cites W2123898323 @default.
• W2075951102 cites W2126219914 @default.
• W2075951102 cites W2126524332 @default.
• W2075951102 cites W2129020678 @default.
• W2075951102 cites W2131614959 @default.
• W2075951102 cites W2134092731 @default.
• W2075951102 cites W2136316199 @default.
• W2075951102 cites W2140507884 @default.
• W2075951102 cites W2140948740 @default.
• W2075951102 cites W2142437744 @default.
• W2075951102 cites W2145942144 @default.
• W2075951102 cites W2150926065 @default.
• W2075951102 cites W2152098836 @default.
• W2075951102 cites W2152689720 @default.
• W2075951102 cites W2153459302 @default.
• W2075951102 cites W2153739292 @default.
• W2075951102 cites W2159657778 @default.
• W2075951102 cites W2162515865 @default.
• W2075951102 cites W2163504077 @default.
• W2075951102 cites W2165093821 @default.
• W2075951102 cites W2166468869 @default.
• W2075951102 cites W2169805130 @default.
• W2075951102 cites W2172095074 @default.
• W2075951102 cites W297331893 @default.
• W2075951102 cites W4245546812 @default.
• W2075951102 doi "https://doi.org/10.1371/journal.pbio.1000213" @default.
• W2075951102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2749941" @default.
• W2075951102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19806183" @default.
• W2075951102 hasPublicationYear "2009" @default.
• W2075951102 type Work @default.

• next