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• W2075963205 abstract "To evaluate the expression of the genes COL1A1, COL1A2, COL3A1 and COL5A1 in the glenohumeral capsule of patients with traumatic anterior instability of the shoulder.Samples from the glenohumeral capsule of 18 patients with traumatic anterior instability of the shoulder were evaluated. Male patients with a positive grip test and a Bankart lesion seen on magnetic resonance imaging were included. All the patients had suffered more than one episode of shoulder dislocation. Samples were collected from the injured glenohumeral capsule (anteroinferior region) and from the macroscopically unaffected region (anterosuperior region) of each patient. The expression of collagen genes was evaluated using the polymerase chain reaction after reverse transcription with quantitative analysis (qRT-PCR).The expression of COL1A1, COL1A2 and COL3A1 did not differ between the two regions of the shoulder capsule. However, it was observed that the expression of COL5A1 was significantly lower in the anteroinferior region than in the anterosuperior region (median ± interquartile range: 0.057 ± 0.052 vs. 0.155 ± 0.398; p = 0.028) of the glenohumeral capsule.The affected region of the glenohumeral capsule in patients with shoulder instability presented reduced expression of COL5A1.Avaliar a expressão dos genes COL1A1, COL1A2, COL3A1 e COL5A1 na cápsula glenoumeral de pacientes com instabilidade anterior traumática do ombro.Foram avaliadas amostras de cápsula glenoumeral de 18 pacientes com instabilidade anterior traumática do ombro. Foram incluídos pacientes masculinos, com teste de apreensão positivo e lesão de Bankart no exame de ressonância magnética. Todos os pacientes sofreram mais de um episódio de luxação do ombro. Foram coletadas amostras da cápsula glenoumeral lesionada (região anteroinferior) e da região macroscopicamente não afetada (região anterossuperior) de cada paciente. A expressão dos genes de colágeno foi avaliada por reação em cadeia da polimerase após transcrição reversa com análise quantitativa (qRT-PCR).A expressão de COL1A1, COL1A2 e COL3A1 não diferiu entre as duas regiões da cápsula do ombro. No entanto, foi observado que a expressão de COL5A1 estava significantemente reduzida na região anteroinferior em relação à região anterossuperior (mediana ± intervalo interquartílico: 0,057 ± 0,052 vs 0,155 ± 0,398; p = 0,028) da cápsula glenoumeral.A região afetada da cápsula glenoumeral de pacientes com instabilidade do ombro apresentou uma expressão reduzida de COL5A1." @default.
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• W2075963205 date "2014-11-01" @default.
• W2075963205 modified "2023-10-02" @default.
• W2075963205 title "Profile of collagen gene expression in the glenohumeral capsule of patients with traumatic anterior instability of the shoulder" @default.
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• W2075963205 doi "https://doi.org/10.1016/j.rboe.2014.10.008" @default.
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