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- W2075966704 abstract "RMA-S is an antigen processing-defective cell line, obtained from a Rauscher virus-induced tumor. The cells express only a low level of cell surface major histocompatibility complex (MHC) class I molecules, which are supposed to be devoid of internally derived antigenic peptides. We investigated Rauscher virus expression and Rauscher peptide presentation to virus-specific cytotoxic T lymphocytes (CTL) by this cell line. Viral proteins are expressed properly, both intracellularly and at the cell surface of RMA-S. Rauscher peptides are presented to virus-specific CTL in the groove of both the class I H-2Kb and Db molecules, but at a low level. Culture of RMA-S cells at room temperature increases their susceptibility to CTL. The RMA-S defect thus affects, but not totally abrogates, Rauscher peptide presentation by MHC class I molecules via the endogenous pathway. This indicates that the RMA-S antigen processing deficit is not absolute." @default.
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- W2075966704 date "1992-06-01" @default.
- W2075966704 modified "2023-10-04" @default.
- W2075966704 title "Cytotoxic T lymphocytes against the antigen-processing-defective RMA-S tumor cell line" @default.
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- W2075966704 doi "https://doi.org/10.1002/eji.1830220644" @default.
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