FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075976696> ?p ?o ?g. }

• W2075976696 abstract "Primary cutaneous γδ T-cell lymphoma and hemophagocytic syndrome (HPS) is a very rare disease process with only 41 cases of this type of lymphoma published to date. We report the case of a 56-year-old woman who developed high-grade fevers and multiple nonhealing bilateral lower extremity ulcers associated with a recent diagnosis of Ackerman syndrome. Multiple lesion biopsies yielded a differential diagnosis including sarcoidosis and lupus panniculitis. Each biopsy site developed into a poorly healing wound. After extensive rheumatologic and dermatologic workup, failed courses of hyperbaric oxygen and corticosteroids, and the development of worsening fevers, the diagnosis of γδ T-cell lymphoma was made. The objective of this article was to illustrate a very rare case of a rapidly progressing cutaneous lymphoma while stressing the importance of a surgical approach to nonhealing wounds and biopsy in chronic wounds.An aggressive multidisciplinary approach including infectious disease, hematology/oncology, nephrology, plastic surgery, and interventional pulmonology was used. Medical approaches included several courses of corticosteroids and antineoplastics. Our surgical approach included numerous excision and debridements of her nonhealing ulcers with removal of necrotic tissue. It also included placement of cadaveric epidermal graft, and bovine tendon collagen cross-linked with glycosaminoglycans with a silicone matrix bilayer (Integra, Plainsboro, NJ) combined with multiple local myocutaneous advancement flaps. This approach demonstrated clinical improvement in wound healing. Pathological examination of several lesions included immunohistochemistry staining, flow cytometry, and molecular studies.The diagnosis of primary cutaneous γδ T-cell lymphoma was made based on a pathology specimen. Subsequent imaging showed numerous pulmonary nodules later determined to be pulmonary Aspergillosis. Additionally, she developed a constellation of clinical and laboratory features defined as the HPS. Despite medical therapy and improved wound healing, she died to seizures that left her comatose, thought to be secondary to central nervous system advancement of her HPS. The patient eventually died after care was withdrawn.Cutaneous forms of lymphoma must be considered in the differential diagnosis of atypical cutaneous lesions or nonhealing wounds. There should be no delay in performing a skin biopsy to obtain a tissue diagnosis. A surgical approach to wounds clearly demonstrates improved wound healing." @default.
• W2075976696 created "2016-06-24" @default.
• W2075976696 creator A5000577194 @default.
• W2075976696 creator A5004925862 @default.
• W2075976696 creator A5018841318 @default.
• W2075976696 creator A5068390800 @default.
• W2075976696 creator A5087644608 @default.
• W2075976696 date "2014-07-04" @default.
• W2075976696 modified "2023-09-24" @default.
• W2075976696 title "Primary Cutaneous γδ T-Cell Lymphoma and Hemophagocytic Syndrome" @default.
• W2075976696 cites W1489917756 @default.
• W2075976696 cites W1605230984 @default.
• W2075976696 cites W1965536458 @default.
• W2075976696 cites W1976541396 @default.
• W2075976696 cites W1982306800 @default.
• W2075976696 cites W1998646967 @default.
• W2075976696 cites W2027715631 @default.
• W2075976696 cites W2042212914 @default.
• W2075976696 cites W2082123948 @default.
• W2075976696 cites W2096160655 @default.
• W2075976696 cites W2107271360 @default.
• W2075976696 cites W2145721186 @default.
• W2075976696 cites W2166380116 @default.
• W2075976696 doi "https://doi.org/10.1097/sap.0000000000000165" @default.
• W2075976696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25003465" @default.
• W2075976696 hasPublicationYear "2014" @default.
• W2075976696 type Work @default.
• W2075976696 sameAs 2075976696 @default.
• W2075976696 citedByCount "1" @default.
• W2075976696 countsByYear W20759766962017 @default.
• W2075976696 crossrefType "journal-article" @default.
• W2075976696 hasAuthorship W2075976696A5000577194 @default.
• W2075976696 hasAuthorship W2075976696A5004925862 @default.
• W2075976696 hasAuthorship W2075976696A5018841318 @default.
• W2075976696 hasAuthorship W2075976696A5068390800 @default.
• W2075976696 hasAuthorship W2075976696A5087644608 @default.
• W2075976696 hasConcept C141071460 @default.
• W2075976696 hasConcept C142724271 @default.
• W2075976696 hasConcept C16005928 @default.
• W2075976696 hasConcept C2775934546 @default.
• W2075976696 hasConcept C2777756187 @default.
• W2075976696 hasConcept C2779338263 @default.
• W2075976696 hasConcept C2780439664 @default.
• W2075976696 hasConcept C2780801072 @default.
• W2075976696 hasConcept C2780954659 @default.
• W2075976696 hasConcept C71924100 @default.
• W2075976696 hasConceptScore W2075976696C141071460 @default.
• W2075976696 hasConceptScore W2075976696C142724271 @default.
• W2075976696 hasConceptScore W2075976696C16005928 @default.
• W2075976696 hasConceptScore W2075976696C2775934546 @default.
• W2075976696 hasConceptScore W2075976696C2777756187 @default.
• W2075976696 hasConceptScore W2075976696C2779338263 @default.
• W2075976696 hasConceptScore W2075976696C2780439664 @default.
• W2075976696 hasConceptScore W2075976696C2780801072 @default.
• W2075976696 hasConceptScore W2075976696C2780954659 @default.
• W2075976696 hasConceptScore W2075976696C71924100 @default.
• W2075976696 hasLocation W20759766961 @default.
• W2075976696 hasLocation W20759766962 @default.
• W2075976696 hasOpenAccess W2075976696 @default.
• W2075976696 hasPrimaryLocation W20759766961 @default.
• W2075976696 hasRelatedWork W1999839269 @default.
• W2075976696 hasRelatedWork W2000641590 @default.
• W2075976696 hasRelatedWork W2019211255 @default.
• W2075976696 hasRelatedWork W2129617682 @default.
• W2075976696 hasRelatedWork W2270057371 @default.
• W2075976696 hasRelatedWork W2278841397 @default.
• W2075976696 hasRelatedWork W2354652759 @default.
• W2075976696 hasRelatedWork W2364743497 @default.
• W2075976696 hasRelatedWork W3113816815 @default.
• W2075976696 hasRelatedWork W4200066940 @default.
• W2075976696 hasVolume "Publish Ahead of Print" @default.
• W2075976696 isParatext "false" @default.
• W2075976696 isRetracted "false" @default.
• W2075976696 magId "2075976696" @default.
• W2075976696 workType "article" @default.