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- W2075983232 abstract "Main studies on Streptomyces, especially S. griseus, during about thirty years of the author’s career are outlined. 1. Studies on streptomycin biosynthesis using resting mycelium-suspension culture of S. griseus revealed the following; 1) Streptomycin 6-phosphate is the final precursor, which is converted to streptomycin by a specific alkaline phosphatase, 2) Streptomycin 6- phosphotransferase contributes to self-protection from a toxic effect of streptomycin, and 3) Suppression of the phospholipid cycle of cell wall synthesis results in the accumulation of glucosamine 6-phosphate in the resting mycelium and the enhancement of streptomycin production 2. Genetic studies provided the following; 1) S. griseus has two genes contributing to self-protection against streptomycin, 2) Pleiotropic mutants were obtained at a high frequency by incubating mycelium under stress condition for growth, and 3) Physical macrorestriction map of S. griseus 2247 strain was constructed." @default.
- W2075983232 created "2016-06-24" @default.
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- W2075983232 date "1997-01-01" @default.
- W2075983232 modified "2023-09-24" @default.
- W2075983232 title "Biochemical and Genetic Studies on Secondary Metabolism." @default.
- W2075983232 doi "https://doi.org/10.3209/saj.11_80" @default.
- W2075983232 hasPublicationYear "1997" @default.
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