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• W2075985945 abstract "Angiogenesis is the focus of therapeutic efforts to promote new vessel development in damaged tissues. Conversely, inhibiting endothelial cell growth and survival is a strategy to treat various proliferative diseases. Much evidence indicates that VEGF is a key mediator of angiogenesis. Recently, a novel angiogenic mitogen with tissue-specific expression and target selectivity was characterized. Human endocrine gland derived vascular endothelial growth factor (EG-VEGF) is selectively expressed in steroidogenic glands and promotes growth of endocrine gland endothelium. The identification of tissue-selective angiogenic factors raises the possibility that other secreted molecules in this class exist. The potential advantage of tissue-specific angiogenic therapeutics may be the reduction of systemic side effects. Additionally, these peptides or their receptors may be attractive targets for inhibition in several disorders." @default.
• W2075985945 created "2016-06-24" @default.
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• W2075985945 date "2004-04-01" @default.
• W2075985945 modified "2023-10-18" @default.
• W2075985945 title "EG-VEGF: A Novel Mediator of Endocrine-Specific Angiogenesis, Endothelial Phenotype, and Function" @default.
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• W2075985945 doi "https://doi.org/10.1196/annals.1294.005" @default.
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