FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075989839> ?p ?o ?g. }

• W2075989839 endingPage "57" @default.
• W2075989839 startingPage "48" @default.
• W2075989839 abstract "Cancer stem cells (CSCs) are involved in tumorigenesis and progression of prostate cancer (PCa). Conventional anticancer therapeutics failed to eradicate CSCs, which may eventually lead to the disease relapse and metastasis. Therefore, targeting prostate CSCs may be an ideal strategy to cure PCa. Genistein is a major isoflavone constituent of soybeans and soy products, which has been shown to exhibit potent anticancer effect on many cancers. We have previously reported that genistein can inhibit PCa cell invasion by reversing epithelial to mesenchymal transition, suggesting that genistein may be effective against metastatic PCa. In addition, we have recently demonstrated that PCa tumorsphere cells (TCs) possess CSC properties. Here, we found that tumorsphere formation and colony formation of Pca cells were noticeably suppressed in the presence of genistein. Pretreatment of PCa TCs with genistein also suppressed tumorigenicity in vivo. Additionally, genistein treatment inhibited tumor growth of PCa TCs. Further studies showed that genistein treatment not only led to the down-regulation of PCa CSC markers CD44 in vitro and in vivo, but also inhibited Hedgehog-Gli1 pathway, which may contribute to the anti-CSC effect of genistein in PCa TCs. Therefore, our findings demonstrated that genistein may be a dietary phytochemical with potential to target prostate CSCs." @default.
• W2075989839 created "2016-06-24" @default.
• W2075989839 creator A5001451095 @default.
• W2075989839 creator A5009232538 @default.
• W2075989839 creator A5013376200 @default.
• W2075989839 creator A5036505611 @default.
• W2075989839 creator A5038077662 @default.
• W2075989839 creator A5050483846 @default.
• W2075989839 creator A5073746039 @default.
• W2075989839 creator A5074115567 @default.
• W2075989839 creator A5075889094 @default.
• W2075989839 creator A5086730562 @default.
• W2075989839 creator A5086783805 @default.
• W2075989839 date "2012-10-01" @default.
• W2075989839 modified "2023-10-03" @default.
• W2075989839 title "Genistein inhibits the stemness properties of prostate cancer cells through targeting Hedgehog–Gli1 pathway" @default.
• W2075989839 cites W152867610 @default.
• W2075989839 cites W1966912177 @default.
• W2075989839 cites W1980658808 @default.
• W2075989839 cites W1982396632 @default.
• W2075989839 cites W1990361620 @default.
• W2075989839 cites W1999356404 @default.
• W2075989839 cites W2001544973 @default.
• W2075989839 cites W2001663331 @default.
• W2075989839 cites W2004419844 @default.
• W2075989839 cites W2004624656 @default.
• W2075989839 cites W2012614375 @default.
• W2075989839 cites W2017381488 @default.
• W2075989839 cites W2018649033 @default.
• W2075989839 cites W2019264784 @default.
• W2075989839 cites W2020046515 @default.
• W2075989839 cites W2023427658 @default.
• W2075989839 cites W2028798336 @default.
• W2075989839 cites W2030161097 @default.
• W2075989839 cites W2051055358 @default.
• W2075989839 cites W2051204314 @default.
• W2075989839 cites W2053687744 @default.
• W2075989839 cites W2055831122 @default.
• W2075989839 cites W2075463028 @default.
• W2075989839 cites W2089848303 @default.
• W2075989839 cites W2098388107 @default.
• W2075989839 cites W2099613822 @default.
• W2075989839 cites W2102085111 @default.
• W2075989839 cites W2111840545 @default.
• W2075989839 cites W2112501269 @default.
• W2075989839 cites W2113780262 @default.
• W2075989839 cites W2115886860 @default.
• W2075989839 cites W2117120020 @default.
• W2075989839 cites W2122147062 @default.
• W2075989839 cites W2126512953 @default.
• W2075989839 cites W2140350596 @default.
• W2075989839 cites W2141417189 @default.
• W2075989839 cites W2143350625 @default.
• W2075989839 cites W2146854566 @default.
• W2075989839 cites W2150079828 @default.
• W2075989839 cites W2158734599 @default.
• W2075989839 cites W2167366196 @default.
• W2075989839 doi "https://doi.org/10.1016/j.canlet.2012.03.037" @default.
• W2075989839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22484470" @default.
• W2075989839 hasPublicationYear "2012" @default.
• W2075989839 type Work @default.
• W2075989839 sameAs 2075989839 @default.
• W2075989839 citedByCount "98" @default.
• W2075989839 countsByYear W20759898392012 @default.
• W2075989839 countsByYear W20759898392013 @default.
• W2075989839 countsByYear W20759898392014 @default.
• W2075989839 countsByYear W20759898392015 @default.
• W2075989839 countsByYear W20759898392016 @default.
• W2075989839 countsByYear W20759898392017 @default.
• W2075989839 countsByYear W20759898392018 @default.
• W2075989839 countsByYear W20759898392019 @default.
• W2075989839 countsByYear W20759898392020 @default.
• W2075989839 countsByYear W20759898392021 @default.
• W2075989839 countsByYear W20759898392022 @default.
• W2075989839 countsByYear W20759898392023 @default.
• W2075989839 crossrefType "journal-article" @default.
• W2075989839 hasAuthorship W2075989839A5001451095 @default.
• W2075989839 hasAuthorship W2075989839A5009232538 @default.
• W2075989839 hasAuthorship W2075989839A5013376200 @default.
• W2075989839 hasAuthorship W2075989839A5036505611 @default.
• W2075989839 hasAuthorship W2075989839A5038077662 @default.
• W2075989839 hasAuthorship W2075989839A5050483846 @default.
• W2075989839 hasAuthorship W2075989839A5073746039 @default.
• W2075989839 hasAuthorship W2075989839A5074115567 @default.
• W2075989839 hasAuthorship W2075989839A5075889094 @default.
• W2075989839 hasAuthorship W2075989839A5086730562 @default.
• W2075989839 hasAuthorship W2075989839A5086783805 @default.
• W2075989839 hasConcept C121608353 @default.
• W2075989839 hasConcept C126322002 @default.
• W2075989839 hasConcept C150903083 @default.
• W2075989839 hasConcept C202751555 @default.
• W2075989839 hasConcept C207001950 @default.
• W2075989839 hasConcept C2778298627 @default.
• W2075989839 hasConcept C2778539099 @default.
• W2075989839 hasConcept C2779013556 @default.
• W2075989839 hasConcept C2779933373 @default.
• W2075989839 hasConcept C2780192828 @default.
• W2075989839 hasConcept C2780932548 @default.

• next