FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076001497> ?p ?o ?g. }

• W2076001497 endingPage "241" @default.
• W2076001497 startingPage "236" @default.
• W2076001497 abstract "The proteases encoded by herpesviruses including herpes simplex virus type 1 (HSV-1) and human cytomegalovirus (HCMV) are attractive targets for antiviral drug development because of their important roles in viral replication. We randomly screened a chemical compound library for inhibitory activity against HSV-1 protease. 1,4-Dihydroxynaphthalene and three naphthoquinones were found to be potent inhibitors of HSV-1 protease with IC50 values of 6.4 to 16.9 μM. Inhibitory mode analysis of the compounds against HSV-1 protease suggested that, in spite of structural similarities, only 1,4-dihydroxynaphthalene was a competitive inhibitor, whereas the three naphthoquinones were noncompetitive inhibitors. Among all assayed dihydroxynaphthalene derivatives in the chemical compound library, 1,4-dihydroxynaphthalene proved to be the most potent inhibitor of HSV-1 protease. Therefore, the two hydroxyl groups located at positions 1 and 4 on the naphthalene structure seemed essential for exertion of a potent inhibitory activity against HSV-1 protease. In addition, we have found that these compounds are also potent inhibitors of HCMV protease with extremely low micromolar IC50 values. This differed from the results of inhibitory mode analysis of HSV-1 protease, 1,4-dihydroxynaphthalene was a noncompetitive inhibitor of HCMV protease, and three naphthoquinones were competitive inhibitors. These compounds showed no effective inhibitory activity against several mammalian serine proteases (trypsin, chymotrypsin, kallikrein, plasmin, thrombin and Factor Xa) at 100 μM. These results suggest that 1,4-dihydroxynaphthalene and three naphthoquinones may be useful in the development of nonpeptidic antiherpesvirus agents." @default.
• W2076001497 created "2016-06-24" @default.
• W2076001497 creator A5005778977 @default.
• W2076001497 creator A5007771940 @default.
• W2076001497 creator A5026003800 @default.
• W2076001497 creator A5042039200 @default.
• W2076001497 creator A5054161366 @default.
• W2076001497 date "2001-01-01" @default.
• W2076001497 modified "2023-10-03" @default.
• W2076001497 title "Selective Nonpeptidic Inhibitors of Herpes Simplex Virus Type 1 and Human Cytomegalovirus Proteases." @default.
• W2076001497 cites W112561058 @default.
• W2076001497 cites W1565862097 @default.
• W2076001497 cites W1584262691 @default.
• W2076001497 cites W1590447057 @default.
• W2076001497 cites W1598055931 @default.
• W2076001497 cites W1608297032 @default.
• W2076001497 cites W1628209714 @default.
• W2076001497 cites W1850094018 @default.
• W2076001497 cites W1964578157 @default.
• W2076001497 cites W1967976820 @default.
• W2076001497 cites W1979843753 @default.
• W2076001497 cites W1983530943 @default.
• W2076001497 cites W1992168782 @default.
• W2076001497 cites W2002611102 @default.
• W2076001497 cites W2003326843 @default.
• W2076001497 cites W2003588859 @default.
• W2076001497 cites W2011303295 @default.
• W2076001497 cites W2016386097 @default.
• W2076001497 cites W2020409753 @default.
• W2076001497 cites W2022357516 @default.
• W2076001497 cites W2030505928 @default.
• W2076001497 cites W2040628882 @default.
• W2076001497 cites W2056650797 @default.
• W2076001497 cites W2057226112 @default.
• W2076001497 cites W2073226435 @default.
• W2076001497 cites W2093599228 @default.
• W2076001497 cites W2098249110 @default.
• W2076001497 cites W2099711455 @default.
• W2076001497 cites W2162907901 @default.
• W2076001497 cites W2952668054 @default.
• W2076001497 cites W4249344507 @default.
• W2076001497 doi "https://doi.org/10.1248/bpb.24.236" @default.
• W2076001497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11256477" @default.
• W2076001497 hasPublicationYear "2001" @default.
• W2076001497 type Work @default.
• W2076001497 sameAs 2076001497 @default.
• W2076001497 citedByCount "11" @default.
• W2076001497 countsByYear W20760014972017 @default.
• W2076001497 countsByYear W20760014972018 @default.
• W2076001497 crossrefType "journal-article" @default.
• W2076001497 hasAuthorship W2076001497A5005778977 @default.
• W2076001497 hasAuthorship W2076001497A5007771940 @default.
• W2076001497 hasAuthorship W2076001497A5026003800 @default.
• W2076001497 hasAuthorship W2076001497A5042039200 @default.
• W2076001497 hasAuthorship W2076001497A5054161366 @default.
• W2076001497 hasBestOaLocation W20760014971 @default.
• W2076001497 hasConcept C142462285 @default.
• W2076001497 hasConcept C159047783 @default.
• W2076001497 hasConcept C181199279 @default.
• W2076001497 hasConcept C182220744 @default.
• W2076001497 hasConcept C185592680 @default.
• W2076001497 hasConcept C202751555 @default.
• W2076001497 hasConcept C2522874641 @default.
• W2076001497 hasConcept C2776714187 @default.
• W2076001497 hasConcept C2776980637 @default.
• W2076001497 hasConcept C2777752497 @default.
• W2076001497 hasConcept C2777807008 @default.
• W2076001497 hasConcept C2781143361 @default.
• W2076001497 hasConcept C2781196997 @default.
• W2076001497 hasConcept C2993143319 @default.
• W2076001497 hasConcept C55493867 @default.
• W2076001497 hasConcept C86803240 @default.
• W2076001497 hasConceptScore W2076001497C142462285 @default.
• W2076001497 hasConceptScore W2076001497C159047783 @default.
• W2076001497 hasConceptScore W2076001497C181199279 @default.
• W2076001497 hasConceptScore W2076001497C182220744 @default.
• W2076001497 hasConceptScore W2076001497C185592680 @default.
• W2076001497 hasConceptScore W2076001497C202751555 @default.
• W2076001497 hasConceptScore W2076001497C2522874641 @default.
• W2076001497 hasConceptScore W2076001497C2776714187 @default.
• W2076001497 hasConceptScore W2076001497C2776980637 @default.
• W2076001497 hasConceptScore W2076001497C2777752497 @default.
• W2076001497 hasConceptScore W2076001497C2777807008 @default.
• W2076001497 hasConceptScore W2076001497C2781143361 @default.
• W2076001497 hasConceptScore W2076001497C2781196997 @default.
• W2076001497 hasConceptScore W2076001497C2993143319 @default.
• W2076001497 hasConceptScore W2076001497C55493867 @default.
• W2076001497 hasConceptScore W2076001497C86803240 @default.
• W2076001497 hasIssue "3" @default.
• W2076001497 hasLocation W20760014971 @default.
• W2076001497 hasLocation W20760014972 @default.
• W2076001497 hasOpenAccess W2076001497 @default.
• W2076001497 hasPrimaryLocation W20760014971 @default.
• W2076001497 hasRelatedWork W1964717963 @default.
• W2076001497 hasRelatedWork W1984160343 @default.
• W2076001497 hasRelatedWork W1994927844 @default.
• W2076001497 hasRelatedWork W2026773456 @default.
• W2076001497 hasRelatedWork W2035164956 @default.

• next