Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076001499> ?p ?o ?g. }
- W2076001499 endingPage "e18543" @default.
- W2076001499 startingPage "e18543" @default.
- W2076001499 abstract "The family of type I interferons (IFN), which consists of several IFN-α and one IFN-β, are produced not only after stimulation by viruses, but also after infection with non-viral pathogens. In the course of bacterial infections, these cytokines could be beneficial or detrimental. IFN-β is the primary member of type I IFN that initiates a cascade of IFN-α production. Here we addressed the question which cells are responsible for IFN-β expression after infection with the intracellular pathogen Listeria monocytogenes by using a genetic approach. By means of newly established reporter mice, maximum of IFN-β expression was observed at 24 hours post infection in spleen and, surprisingly, 48 hours post infection in colonized cervical and inguinal lymph nodes. Colonization of lymph nodes was independent of the type I IFN signaling, as well as bacterial dose and strain. Using cell specific reporter function and conditional deletions we could define cells expressing LysM as the major IFN-β producers, with cells formerly defined as Tip-DCs being the highest. Neutrophilic granulocytes, dendritic cells and plasmacytoid dendritic cells did not significantly contribute to type I IFN production." @default.
- W2076001499 created "2016-06-24" @default.
- W2076001499 creator A5028220032 @default.
- W2076001499 creator A5032178490 @default.
- W2076001499 creator A5050358121 @default.
- W2076001499 date "2011-04-11" @default.
- W2076001499 modified "2023-10-18" @default.
- W2076001499 title "Production of IFN-β during Listeria monocytogenes Infection Is Restricted to Monocyte/Macrophage Lineage" @default.
- W2076001499 cites W1488854843 @default.
- W2076001499 cites W1540169912 @default.
- W2076001499 cites W1547883469 @default.
- W2076001499 cites W1595293335 @default.
- W2076001499 cites W1600790350 @default.
- W2076001499 cites W1670789146 @default.
- W2076001499 cites W1673881514 @default.
- W2076001499 cites W1829223 @default.
- W2076001499 cites W1964141567 @default.
- W2076001499 cites W1975764372 @default.
- W2076001499 cites W1976851579 @default.
- W2076001499 cites W1981009477 @default.
- W2076001499 cites W1982758029 @default.
- W2076001499 cites W1990083653 @default.
- W2076001499 cites W1999742985 @default.
- W2076001499 cites W2004724554 @default.
- W2076001499 cites W2012319233 @default.
- W2076001499 cites W2019202919 @default.
- W2076001499 cites W2019596936 @default.
- W2076001499 cites W2023962283 @default.
- W2076001499 cites W2028362431 @default.
- W2076001499 cites W2028554946 @default.
- W2076001499 cites W2028744022 @default.
- W2076001499 cites W2032917789 @default.
- W2076001499 cites W2037890160 @default.
- W2076001499 cites W2039390702 @default.
- W2076001499 cites W2040665228 @default.
- W2076001499 cites W2052313621 @default.
- W2076001499 cites W2054165206 @default.
- W2076001499 cites W2056172754 @default.
- W2076001499 cites W2057521728 @default.
- W2076001499 cites W2078919511 @default.
- W2076001499 cites W2082889122 @default.
- W2076001499 cites W2085237060 @default.
- W2076001499 cites W2088534886 @default.
- W2076001499 cites W2094070743 @default.
- W2076001499 cites W2096372976 @default.
- W2076001499 cites W2097556922 @default.
- W2076001499 cites W2098301173 @default.
- W2076001499 cites W2100820895 @default.
- W2076001499 cites W2108984941 @default.
- W2076001499 cites W2110456507 @default.
- W2076001499 cites W2110864354 @default.
- W2076001499 cites W2113757071 @default.
- W2076001499 cites W2114675972 @default.
- W2076001499 cites W2116601236 @default.
- W2076001499 cites W2119624663 @default.
- W2076001499 cites W2122822209 @default.
- W2076001499 cites W2131808872 @default.
- W2076001499 cites W2135793489 @default.
- W2076001499 cites W2137277739 @default.
- W2076001499 cites W2144601891 @default.
- W2076001499 cites W2146293966 @default.
- W2076001499 cites W2147425141 @default.
- W2076001499 cites W2147819976 @default.
- W2076001499 cites W2148859983 @default.
- W2076001499 cites W2159698564 @default.
- W2076001499 cites W2160217307 @default.
- W2076001499 cites W2161162286 @default.
- W2076001499 cites W2164150624 @default.
- W2076001499 cites W2168282353 @default.
- W2076001499 cites W2168778458 @default.
- W2076001499 doi "https://doi.org/10.1371/journal.pone.0018543" @default.
- W2076001499 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3073975" @default.
- W2076001499 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21494554" @default.
- W2076001499 hasPublicationYear "2011" @default.
- W2076001499 type Work @default.
- W2076001499 sameAs 2076001499 @default.
- W2076001499 citedByCount "55" @default.
- W2076001499 countsByYear W20760014992012 @default.
- W2076001499 countsByYear W20760014992013 @default.
- W2076001499 countsByYear W20760014992014 @default.
- W2076001499 countsByYear W20760014992015 @default.
- W2076001499 countsByYear W20760014992016 @default.
- W2076001499 countsByYear W20760014992017 @default.
- W2076001499 countsByYear W20760014992018 @default.
- W2076001499 countsByYear W20760014992019 @default.
- W2076001499 countsByYear W20760014992020 @default.
- W2076001499 countsByYear W20760014992021 @default.
- W2076001499 countsByYear W20760014992022 @default.
- W2076001499 crossrefType "journal-article" @default.
- W2076001499 hasAuthorship W2076001499A5028220032 @default.
- W2076001499 hasAuthorship W2076001499A5032178490 @default.
- W2076001499 hasAuthorship W2076001499A5050358121 @default.
- W2076001499 hasBestOaLocation W20760014991 @default.
- W2076001499 hasConcept C153726182 @default.
- W2076001499 hasConcept C159047783 @default.
- W2076001499 hasConcept C202751555 @default.
- W2076001499 hasConcept C203014093 @default.
- W2076001499 hasConcept C2776178377 @default.