Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076002167> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2076002167 endingPage "144" @default.
- W2076002167 startingPage "134" @default.
- W2076002167 abstract "Platelets from diabetic humans and animals have been found previously to be hypersensitive to agonists, including thrombin, in vitro but it is unclear if this hypersensitivity also occurs in vivo and leads to a greater thrombotic tendency. In the present study, the effect of diabetes was examined on thrombus formation and vessel wall responses which result from continuous intimal injury induced by indwelling aortic catheters in rabbits. Platelet and fibrin(ogen) associated with the thrombus and damaged aortae were examined. Control or alloxan-induced diabetic rabbits (9–12 months after initial treatment) were injected with 51Cr-labeled autologous platelets and 125I-labeled fibrinogen (prepared from control rabbits) before insertion of indwelling aortic catheters. The anesthetized rabbits were perfused-fixed after 20 hr or 4 days. The dry weight of thrombus that formed was determined and platelet and fibrin(ogen) accumulation in thrombi and on injured aortae were calculated from the associated 51Cr and 125I, respectively. In diabetic rabbits, more platelets accumulated in the thrombi which formed after either 20 hr or 4 days, although the weight of thrombus and net fibrin(ogen) incorporation into the thrombus were not different from corresponding control rabbits. Net platelet and fibrin(ogen) association with the injured aortae were not different between control and diabetic rabbits. It is likely that the increased platelet accumulation in arterial thrombi in diabetic rabbits which results from continuous injury to aortae is a consequence of hypersensitivity of these platelets to thrombin generated in the thrombus and at the sites of vessel injury." @default.
- W2076002167 created "2016-06-24" @default.
- W2076002167 creator A5022245715 @default.
- W2076002167 creator A5057601626 @default.
- W2076002167 creator A5081503393 @default.
- W2076002167 date "1992-10-01" @default.
- W2076002167 modified "2023-09-24" @default.
- W2076002167 title "Increased platelet, but unaltered fibrinogen, accumulation in experimental thrombi in alloxan-induced diabetic rabbits" @default.
- W2076002167 cites W1509349295 @default.
- W2076002167 cites W1968544794 @default.
- W2076002167 cites W1976482686 @default.
- W2076002167 cites W2039969354 @default.
- W2076002167 cites W2040585553 @default.
- W2076002167 cites W2047166809 @default.
- W2076002167 cites W2090338931 @default.
- W2076002167 cites W2090921446 @default.
- W2076002167 cites W2094856121 @default.
- W2076002167 cites W2098951393 @default.
- W2076002167 cites W2100500261 @default.
- W2076002167 cites W2109401564 @default.
- W2076002167 cites W2112538182 @default.
- W2076002167 cites W2141581995 @default.
- W2076002167 cites W2163964990 @default.
- W2076002167 cites W2413305411 @default.
- W2076002167 cites W2417320106 @default.
- W2076002167 cites W2886640752 @default.
- W2076002167 cites W405273222 @default.
- W2076002167 cites W4232352316 @default.
- W2076002167 cites W4234355201 @default.
- W2076002167 cites W4234756550 @default.
- W2076002167 cites W4247046638 @default.
- W2076002167 cites W4250584788 @default.
- W2076002167 cites W4252311197 @default.
- W2076002167 doi "https://doi.org/10.1016/0014-4800(92)90005-v" @default.
- W2076002167 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1426157" @default.
- W2076002167 hasPublicationYear "1992" @default.
- W2076002167 type Work @default.
- W2076002167 sameAs 2076002167 @default.
- W2076002167 citedByCount "4" @default.
- W2076002167 crossrefType "journal-article" @default.
- W2076002167 hasAuthorship W2076002167A5022245715 @default.
- W2076002167 hasAuthorship W2076002167A5057601626 @default.
- W2076002167 hasAuthorship W2076002167A5081503393 @default.
- W2076002167 hasConcept C126322002 @default.
- W2076002167 hasConcept C134018914 @default.
- W2076002167 hasConcept C150903083 @default.
- W2076002167 hasConcept C203014093 @default.
- W2076002167 hasConcept C207001950 @default.
- W2076002167 hasConcept C2777292125 @default.
- W2076002167 hasConcept C2779036427 @default.
- W2076002167 hasConcept C2780868729 @default.
- W2076002167 hasConcept C2781005915 @default.
- W2076002167 hasConcept C2781362458 @default.
- W2076002167 hasConcept C3018697912 @default.
- W2076002167 hasConcept C54173615 @default.
- W2076002167 hasConcept C555293320 @default.
- W2076002167 hasConcept C71924100 @default.
- W2076002167 hasConcept C86803240 @default.
- W2076002167 hasConcept C89560881 @default.
- W2076002167 hasConceptScore W2076002167C126322002 @default.
- W2076002167 hasConceptScore W2076002167C134018914 @default.
- W2076002167 hasConceptScore W2076002167C150903083 @default.
- W2076002167 hasConceptScore W2076002167C203014093 @default.
- W2076002167 hasConceptScore W2076002167C207001950 @default.
- W2076002167 hasConceptScore W2076002167C2777292125 @default.
- W2076002167 hasConceptScore W2076002167C2779036427 @default.
- W2076002167 hasConceptScore W2076002167C2780868729 @default.
- W2076002167 hasConceptScore W2076002167C2781005915 @default.
- W2076002167 hasConceptScore W2076002167C2781362458 @default.
- W2076002167 hasConceptScore W2076002167C3018697912 @default.
- W2076002167 hasConceptScore W2076002167C54173615 @default.
- W2076002167 hasConceptScore W2076002167C555293320 @default.
- W2076002167 hasConceptScore W2076002167C71924100 @default.
- W2076002167 hasConceptScore W2076002167C86803240 @default.
- W2076002167 hasConceptScore W2076002167C89560881 @default.
- W2076002167 hasIssue "2" @default.
- W2076002167 hasLocation W20760021671 @default.
- W2076002167 hasLocation W20760021672 @default.
- W2076002167 hasOpenAccess W2076002167 @default.
- W2076002167 hasPrimaryLocation W20760021671 @default.
- W2076002167 hasRelatedWork W141749963 @default.
- W2076002167 hasRelatedWork W185288001 @default.
- W2076002167 hasRelatedWork W1950564172 @default.
- W2076002167 hasRelatedWork W1982307963 @default.
- W2076002167 hasRelatedWork W1994365113 @default.
- W2076002167 hasRelatedWork W2005974889 @default.
- W2076002167 hasRelatedWork W2015877067 @default.
- W2076002167 hasRelatedWork W2076002167 @default.
- W2076002167 hasRelatedWork W2279781996 @default.
- W2076002167 hasRelatedWork W4246235697 @default.
- W2076002167 hasVolume "57" @default.
- W2076002167 isParatext "false" @default.
- W2076002167 isRetracted "false" @default.
- W2076002167 magId "2076002167" @default.
- W2076002167 workType "article" @default.